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Bibliographic Details
Main Author:	Juan Joel Mosqueda Gualito
Format:	Artículo científico
Language:	es
Published:	Universidad Nacional Autónoma de México 1999
Subjects:	Multidisciplinaria (Ciencias Naturales y Exactas) bovino protección inmunización babesia bovis babesia bigemina
Online Access:	https://www.redalyc.org/articulo.oa?id=42330301
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Evaluación de la patogenicidad y capacidad protectora de un inmunógeno fresco combinado de Babesia bigemina y Babesia bovis Juan Joel Mosqueda Gualito Jesús Antonio Álvarez Martínez Juan Alberto Ramos Aragón Carlos Agustín Vega y Murguía Julio Vicente Figueroa Millán Germinal Jorge Canto Alarcón Multidisciplinaria (Ciencias Naturales y Exactas) bovino protección inmunización babesia bovis babesia bigemina El objetivo del trabajo fue evaluar la inocuidad y la capacidad inmunoprotectora de un inmunógeno combinado deBabesia bigemina y Babesia bovis a una dosis de 108 y 109, respectivamente, bajo un desafío controlado. En el primerexperimento (inocuidad) se utilizaron 16 bovinos Holstein provenientes de una zona libre de garrapatas y negativos aanticuerpos contra Babesia spp, mediante la prueba de inmunofluorescencia indirecta (IFI), los cuales fueron inoculados,vía intramuscular, con 1 X 109 eritrocitos infectados (EI) con una cepa atenuada de B. bigemina y 108 EI de una clonairradiada de B. bovis, ambas derivadas de cultivo in vitro. Se observaron cambios en las constantes fisiológicas a partir deldía 7 y hasta el día 14 posinoculación (PI) en los animales sin verse éstos físicamente afectados. El porcentaje deeritrocitos parasitados (PEP) fue <0.01%. El segundo experimento (inmunogenicidad), se realizó tres meses PI y consistióen el desafío de 8 de los animales del experimento 1 con cepas virulentas de ambas especies del protozoario a una dosis de108 EI de cada una. Cuatro animales adicionales sirvieron como grupo testigo. El grupo inmunizado presentó ligeradisminución en el volumen celular aglomerado (VCA) con temperatura rectal (TR) sin cambios y PEP de 0.06 y <0.01 para B. bigemina y B. bovis, respectivamente. El grupo testigo presentó TR mayor a 400C, disminución del VCA (29%) yel PEP fue de 0.5 para B. bigemina y 0.03 para B. bovis; estos animales requirieron tratamiento para evitar su muerte. Seconcluye que el inmunógeno combinado de B. bigemina y B. bovis a dosis altas no provoca reacciones clínicas severas enanimales susceptibles y proporciona una sólida protección al desafío controlado con cepas virulentas. 1999 artículo científico 0301-5092 https://www.redalyc.org/articulo.oa?id=42330301 es http://www.redalyc.org/revista.oa?id=423 Veterinaria México application/pdf Universidad Nacional Autónoma de México Veterinaria México (México) Num.3 Vol.30

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