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| Format: | Artículo científico |
| Language: | en |
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Universidad Nacional Autónoma de México
2002
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| Online Access: | https://www.redalyc.org/articulo.oa?id=42333208 |
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- Aumento de la resistencia contra la infección experimental murina por Trichinella spiralis utilizando Lactobacillus casei Olga Ixta Rodríguez Alma Rosa Fernández Román Adriana Posadas Beltrán Carlos Ramón Bautista Garfias Multidisciplinaria (Ciencias Naturales y Exactas) NON BALB C MICE SPECIFIC RESISTANCE LACTOBACILLUS CASEI Previous studies demonstrated that Lactobacillus casei induces protective responses in heterogenic mice (NIH)against infection due to parasites such as Hymenolepis nana and Trichinella spiralis. The aim of the present studywas to determine the protection induced by the intraperitoneal (ip) inoculation of viable Lactobacillus casei intocongenic mice against T. spiralis infection. Twenty-two parasite-free female adult BALB/c mice were allocatedat random into four groups (Lc-1, Lc-2, Lc-3 and C) of five to six animals each. Each mouse from groups Lc-1, Lc-2 and Lc-3 was inoculated by the ip route with 1.8 × 109 viable Lactobacillus casei as follows: In Lc-1, ondays 14 and 7; in Lc-2, on days 11 and 4; and in Lc-3, on days 7 and 1. Animals from the control Group(C) did not receive any treatment. All animals from the four groups received 500 T. spiralis infective ISS3 strainlarvae/mouse by the oral route on day 0. Five days later, mice were sacrificed to obtain adult worms from theirintestines. Data was analyzed by the Kruskal-Wallis test. The mean ± standard error of mean (SEM) of T.spiralis adult specimens for Group C was 22 ± 7.1; while for Lc-1, Lc-2 and Lc-3 groups it was of 14 ± 3.6, 12.66± 5.1, and 2 ± 1.2, respectively. Reduction of the worm load related to that of the control group was of 36.4%,42.45% and 90.9% for Lc-1, Lc-2 and Lc-3 groups, respectively. Such a reduction was only significant in theLc-3 Group (P<0.05). Results indicate that viable L. casei inoculated twice (days 7 and 1) in congenic BALB/c induces a significant protective response against T. spiralis infection. 2002 otro 0301-5092 https://www.redalyc.org/articulo.oa?id=42333208 en http://www.redalyc.org/revista.oa?id=423 Veterinaria México application/pdf Universidad Nacional Autónoma de México Veterinaria México (México) Num.2 Vol.33