Inhibidores selectivos de la ciclooxigenasa-2: Usos potenciales en perros
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Universidad Nacional Autónoma de México
2002
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| _version_ | 1876477614410956800 |
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| author | Fernanda Castillo Alcalá |
| author_facet | Fernanda Castillo Alcalá |
| contents | Inhibidores selectivos de la ciclooxigenasa-2: Usos potenciales en perros Fernanda Castillo Alcalá Héctor Sumano López Ignacio Lizárraga Madrigal Multidisciplinaria (Ciencias Naturales y Exactas) COX DOGS NSAIDs CYCLOOXYGENASES 2 SELECTIVE INHIBITORS Use of non-steroidal anti-inflammatory drugs (NSAIDs) in dogs is limited because of the adverse effects theyproduce. All NSAIDs inhibit, by different degrees, the cyclooxygenases (COX), enzymes that exist in at leasttwo isoforms: COX-1 and COX-2. Inhibition of COX-1 is believed to be responsible for the adverse effects ofNSAIDs, whereas inhibition of COX-2 is thought to be related to the therapeutic effects of this class of drugs.This theory, to some extent, seems to be true for humans suffering from osteoarthritis who receive COX-2selective inhibitors. If this hypothesis also applies to dogs, COX-2 selective inhibitors should play animportant role in canine therapeutics. This review highlights relevant physiopathologic aspects of COX-2within the organism (e.g., gastrointestinal tract, kidneys, central nervous system), based on this information,the possible uses and adverse effects of selective COX-2 inhibitors (e.g., celecoxib, nimesulide, NS-398) in dogsare discussed. Clinical-pharmacological information on the use of selective COX-2 inhibitors (e.g., carprofen,celecoxib, nimesulide) specifically obtained from dogs is also presented. 2002 artículo científico 0301-5092 https://www.redalyc.org/articulo.oa?id=42333307 en http://www.redalyc.org/revista.oa?id=423 Veterinaria México application/pdf Universidad Nacional Autónoma de México Veterinaria México (México) Num.3 Vol.33 |
| format | Artículo científico |
| id | redalyc_42333307 |
| institution | Redalyc |
| language | en |
| publishDate | 2002 |
| publisher | Universidad Nacional Autónoma de México |
| spellingShingle | Inhibidores selectivos de la ciclooxigenasa-2: Usos potenciales en perros Fernanda Castillo Alcalá Multidisciplinaria (Ciencias Naturales y Exactas) COX DOGS NSAIDs CYCLOOXYGENASES 2 SELECTIVE INHIBITORS Inhibidores selectivos de la ciclooxigenasa-2: Usos potenciales en perros Fernanda Castillo Alcalá Héctor Sumano López Ignacio Lizárraga Madrigal Multidisciplinaria (Ciencias Naturales y Exactas) COX DOGS NSAIDs CYCLOOXYGENASES 2 SELECTIVE INHIBITORS Use of non-steroidal anti-inflammatory drugs (NSAIDs) in dogs is limited because of the adverse effects theyproduce. All NSAIDs inhibit, by different degrees, the cyclooxygenases (COX), enzymes that exist in at leasttwo isoforms: COX-1 and COX-2. Inhibition of COX-1 is believed to be responsible for the adverse effects ofNSAIDs, whereas inhibition of COX-2 is thought to be related to the therapeutic effects of this class of drugs.This theory, to some extent, seems to be true for humans suffering from osteoarthritis who receive COX-2selective inhibitors. If this hypothesis also applies to dogs, COX-2 selective inhibitors should play animportant role in canine therapeutics. This review highlights relevant physiopathologic aspects of COX-2within the organism (e.g., gastrointestinal tract, kidneys, central nervous system), based on this information,the possible uses and adverse effects of selective COX-2 inhibitors (e.g., celecoxib, nimesulide, NS-398) in dogsare discussed. Clinical-pharmacological information on the use of selective COX-2 inhibitors (e.g., carprofen,celecoxib, nimesulide) specifically obtained from dogs is also presented. 2002 artículo científico 0301-5092 https://www.redalyc.org/articulo.oa?id=42333307 en http://www.redalyc.org/revista.oa?id=423 Veterinaria México application/pdf Universidad Nacional Autónoma de México Veterinaria México (México) Num.3 Vol.33 |
| title | Inhibidores selectivos de la ciclooxigenasa-2: Usos potenciales en perros |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) COX DOGS NSAIDs CYCLOOXYGENASES 2 SELECTIVE INHIBITORS |
| url | https://www.redalyc.org/articulo.oa?id=42333307 |