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Bibliographic Details
Main Author:	D Ibarra-Ríos
Format:	Artículo científico
Language:	es
Published:	Instituto Nacional de Pediatría 2017
Subjects:	Medicina Leucemia neonatal leucemia aguda linfoide leucemia aguda mieloide serie de casos
Online Access:	https://www.redalyc.org/articulo.oa?id=423658489006 https://www.redalyc.org/journal/4236/423658489006/ https://www.redalyc.org/journal/4236/423658489006/html/ https://www.redalyc.org/journal/4236/423658489006/423658489006.epub https://www.redalyc.org/journal/4236/423658489006/movil
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Leucemias neonatales: experiencia en el Hospital Infantil de México Federico Gómez (HIMFG) D Ibarra-Ríos M Zapata-Tarres D Villanueva-García H Peña-del Castillo EM Dorantes-Acosta LE Juárez-Villegas Medicina Leucemia neonatal leucemia aguda linfoide leucemia aguda mieloide serie de casos INTRODUCCIÓN: la leucemia neonatal (o congénita) es aquella diagnosticada en los primeros 30 días tras el nacimiento. Su incidencia se reporta en 1 a 5 por cada millón de recién nacidos vivos (corresponde a menos del 1% de las leucemias en pediatría). OBJETIVO: describir los casos diagnosticados en el Hospital Infantil de México Federico Gómez (HIMFG). PRESENTACIÓN DE LA SERIE DE CASOS: se incluyó pacientes menores de 30 días a los cuales se les realizó el diagnóstico morfológico de leucemias entre el 1º de enero de 1990 y el 1º de junio del 2012 en el HIMFG. RESULTADOS: en los 12 años del estudio se identificaron 3,061 casos de leucemias, de los cuales sólo cinco expedientes correspondieron a leucemias neonatales. Se describen tres pacientes femeninos y dos masculinos, con edad media al diagnóstico de 21 días (17-26 días), tratándose con mayor frecuencia de leucemia mieloide (LMA) en tres casos (60%) y leucemia linfoide en dos pacientes. Un caso de LMA asociado a síndrome de Down. En ningún caso se encontraron translocaciones de riesgo. Cuatro pacientes (80%) recibieron manejo para síndrome de lisis tumoral. Cuatro pacientes fallecieron con una mediana de edad de 84 días (57-176 días). El paciente que sobrevivió recibió tratamiento con doxorrubicina y metotrexate al 50% y en su último seguimiento a los tres años de edad continuaba en remisión. CONCLUSIONES: la presentación de los casos corresponde a la reportada en literatura con respecto a frecuencias de leucemias linfoides y mieloides. La supervivencia global a largo plazo fue del 20% (33% para las mieloides) con un solo paciente en remisión. Este padecimiento tiene un pronóstico fatal que puede mejorar con el diagnóstico oportuno (incluso prenatal) y manejo con quimioterapia intensiva. Ésta es la serie más grande de leucemias neonatales reportada en México. 2017 otro 0186-2391 https://www.redalyc.org/articulo.oa?id=423658489006 https://www.redalyc.org/journal/4236/423658489006/ https://www.redalyc.org/journal/4236/423658489006/html/ https://www.redalyc.org/journal/4236/423658489006/423658489006.epub https://www.redalyc.org/journal/4236/423658489006/movil 10.18233/APM38No6pp394-4011507 es http://www.redalyc.org/revista.oa?id=4236 Acta Pediátrica de México application/pdf Instituto Nacional de Pediatría Acta Pediátrica de México (México) Num.6 Vol.38

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