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| Format: | Artículo científico |
| Language: | en |
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Universidade Estadual Paulista Júlio de Mesquita Filho
2008
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| Online Access: | https://www.redalyc.org/articulo.oa?id=42915808007 |
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Table of Contents:
- Highly sensitive spectrophotometric methods for the determination of olanzapine H. D. Revanasiddappa M. A. Veena Química Ce(IV) Olanzapine thymol blue spectrophotometry Iodinemonochloride Highly sensitive and selective spectrophotometric methods (A and B) were developed for the determination of micro amounts of olanzapine (OLZ). Method A (direct method) is based on the oxidation of olanzapine with a known excess of iodine monochloride (ICl) in an acidic medium. Under the same condition, thymol blue was iodinated by unreacted ICl, and the absorbance of uniodinated thymol blue was measured at 536 nm. The decrease in ICl concentration is a measure of drug concentration. In method B (indirect method), oxidation of OLZ by a known excess of Ce(IV) in sulfuric acid medium followed by the reaction of unreacted Ce(IV) with leuco crystal violet (LCV) to crystal violet (CV), which is measured in an acetate buffer medium ( pH 4.9) at 580 nm. These methods obey the Beer's law in the concentration range of 0.2-1.6 µg mL-1 (method A) and 0.1-1.4 µg mL-1 (method B). The developed procedures have been successfully applied to the determination of OLZ in pure and in dosage forms. The results exhibit no interference from the presence of excipients. The reliability of the methods was established by parallel determination of OLZ against the reference method. 2008 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42915808007 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.3 Vol.33