NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE
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| Format: | Artículo científico |
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Universidade Estadual Paulista Júlio de Mesquita Filho
2010
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| author | B. Narayana |
| author_facet | B. Narayana |
| contents | NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE B. Narayana K. Veena K. Ashwani Divya. N. Shetty Química Crystal violet Malachite green Spectrophotometry Ceric ammonium sulphate Ranitidine hydrochloride A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer's law is obeyed in the concentration range of 0.4-8.0 µg/ ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6µg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell's sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms. 2010 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42915812010 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.3 Vol.35 |
| format | Artículo científico |
| id | redalyc_42915812010 |
| institution | Redalyc |
| language | en |
| publishDate | 2010 |
| publisher | Universidade Estadual Paulista Júlio de Mesquita Filho |
| spellingShingle | NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE B. Narayana Química Crystal violet Malachite green Spectrophotometry Ceric ammonium sulphate Ranitidine hydrochloride NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE B. Narayana K. Veena K. Ashwani Divya. N. Shetty Química Crystal violet Malachite green Spectrophotometry Ceric ammonium sulphate Ranitidine hydrochloride A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer's law is obeyed in the concentration range of 0.4-8.0 µg/ ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6µg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell's sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms. 2010 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42915812010 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.3 Vol.35 |
| title | NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE |
| topic | Química Crystal violet Malachite green Spectrophotometry Ceric ammonium sulphate Ranitidine hydrochloride |
| url | https://www.redalyc.org/articulo.oa?id=42915812010 |