Potentiometric determination of captopril in pharmaceutical formulations
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| Format: | Artículo científico |
| Language: | en |
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Universidade Estadual Paulista Júlio de Mesquita Filho
2003
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| _version_ | 1876476772363534336 |
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| author | L. Pezza |
| author_facet | L. Pezza |
| contents | Potentiometric determination of captopril in pharmaceutical formulations L. Pezza H. R. Pezza A. O. Santini P. R. da S. Ribeiro Química captopril pharmaceutical formulations potentiometric determination A simple, precise, rapid and low-cost potentiometric method for captopril determination in pureform and in pharmaceutical preparations is proposed. Captopril present in tablets containing knownquantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH electrode,coupled to an autotitrator. No interferences were observed in the presence of common componentsof the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesiumstearate. The analytical results obtained by applying the proposed method compared very favorably withthose obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril fromvarious tablet dosage formulations range from 98.0 to 102.0%. 2003 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42928105 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.1 Vol.28 |
| format | Artículo científico |
| id | redalyc_42928105 |
| institution | Redalyc |
| language | en |
| publishDate | 2003 |
| publisher | Universidade Estadual Paulista Júlio de Mesquita Filho |
| spellingShingle | Potentiometric determination of captopril in pharmaceutical formulations L. Pezza Química captopril pharmaceutical formulations potentiometric determination Potentiometric determination of captopril in pharmaceutical formulations L. Pezza H. R. Pezza A. O. Santini P. R. da S. Ribeiro Química captopril pharmaceutical formulations potentiometric determination A simple, precise, rapid and low-cost potentiometric method for captopril determination in pureform and in pharmaceutical preparations is proposed. Captopril present in tablets containing knownquantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH electrode,coupled to an autotitrator. No interferences were observed in the presence of common componentsof the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesiumstearate. The analytical results obtained by applying the proposed method compared very favorably withthose obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril fromvarious tablet dosage formulations range from 98.0 to 102.0%. 2003 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42928105 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.1 Vol.28 |
| title | Potentiometric determination of captopril in pharmaceutical formulations |
| topic | Química captopril pharmaceutical formulations potentiometric determination |
| url | https://www.redalyc.org/articulo.oa?id=42928105 |