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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Universidade Estadual Paulista Júlio de Mesquita Filho
2004
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=42929110 |
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Sommario:
- Flow injection spectrophotometric determination of adrenaline using a solid-phase reactor containing triiodide ions immobilized in an anion-exchange resin H. J. Vieira O. Fatibello-Filho Química solid adrenaline phase reactor triiodide ions pharmaceutical formulations A flow injection spectrophotometric procedure with on-line solid-phase reactor containingion triiodide immobilized in an anion-exchange resin is proposed for the determination of adrenaline(epinephrine) in pharmaceutical products. Adrenaline is oxidized by triiodide ion immobilized in ananionic-exchange resin yielding adrenochrome which is transported by the carrier solution and detectedat a wavelength of 488 nm. Adrenaline was determined in three pharmaceutical products in the 6.4 x 10-6 to 3.0 x 10-4 mol L-1 concentration range with a detection limit of 4.8 x 10-7 mol L-1. The recovery of thisanalyte in three samples ranged from 96.0 to 105 %. The analytical frequency was 80 determinations perhour and the RSDs were less than 1 % for adrenaline concentrations of 6.4 x 10-5 and 2.0 x 10-4 mol L-1(n=10). A paired t-test showed that all results obtained for adrenaline in commercial formulations usingthe proposed flow injection procedure and a spectrophotometric batch procedure agree at the 95%confidence level. 2004 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42929110 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.1 Vol.29