Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Universidade Estadual Paulista Júlio de Mesquita Filho
2005
|
| Schlagworte: | |
| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=42930202 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1866817092928405504 |
|---|---|
| author | M. A. Gotardo |
| author_facet | M. A. Gotardo |
| contents | Determination of hydrochlorothiazide in pharmaceutical formulations by diffuse reflectance spectroscopy M. A. Gotardo L. Pezza H. R. Pezza Química spot test hydrochlorothiazide dimethylaminocinnamaldehyde diffuse reflectance spectroscopy This paper describes a method for quantitative spot test analysis of hydrochlorothiazide using diffuse reflectance spectroscopy. The reflectance measurements were performed analyzing the colored compound (l = 585 nm) produced from the reaction between hydrochlorothiazide and p-dimethylaminocinnamaldehyde (PDAC) in acid medium. This reaction occurred on filter paper after heating to 80ºC for 8 minutes. Factorial designs allowed varying multiple reaction factors simultaneously in order to obtain the best reaction conditions. These factors included heating temperature, heating time, acid volume and PDAC volume. The linearity was studied in the range of 3.36x10-2 to 1.01x10-1 mol L-1 with a correlation coefficient of 0.998. The limit of detection was estimated to be 1.32x102 mol L-1. Commercial samples were analyzed using the proposed method and the results were favorably compared with those of the United States Pharmacopeia method, showing that quantitative spot test analysis by diffuse reflectance could be successfully used to determine hydrochlorothiazide in medicines. 2005 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42930202 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.2 Vol.30 |
| format | Artículo científico |
| id | redalyc_42930202 |
| language | en |
| publishDate | 2005 |
| publisher | Universidade Estadual Paulista Júlio de Mesquita Filho |
| spellingShingle | Determination of hydrochlorothiazide in pharmaceutical formulations by diffuse reflectance spectroscopy M. A. Gotardo Química spot test hydrochlorothiazide dimethylaminocinnamaldehyde diffuse reflectance spectroscopy Determination of hydrochlorothiazide in pharmaceutical formulations by diffuse reflectance spectroscopy M. A. Gotardo L. Pezza H. R. Pezza Química spot test hydrochlorothiazide dimethylaminocinnamaldehyde diffuse reflectance spectroscopy This paper describes a method for quantitative spot test analysis of hydrochlorothiazide using diffuse reflectance spectroscopy. The reflectance measurements were performed analyzing the colored compound (l = 585 nm) produced from the reaction between hydrochlorothiazide and p-dimethylaminocinnamaldehyde (PDAC) in acid medium. This reaction occurred on filter paper after heating to 80ºC for 8 minutes. Factorial designs allowed varying multiple reaction factors simultaneously in order to obtain the best reaction conditions. These factors included heating temperature, heating time, acid volume and PDAC volume. The linearity was studied in the range of 3.36x10-2 to 1.01x10-1 mol L-1 with a correlation coefficient of 0.998. The limit of detection was estimated to be 1.32x102 mol L-1. Commercial samples were analyzed using the proposed method and the results were favorably compared with those of the United States Pharmacopeia method, showing that quantitative spot test analysis by diffuse reflectance could be successfully used to determine hydrochlorothiazide in medicines. 2005 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42930202 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.2 Vol.30 |
| title | Determination of hydrochlorothiazide in pharmaceutical formulations by diffuse reflectance spectroscopy |
| topic | Química spot test hydrochlorothiazide dimethylaminocinnamaldehyde diffuse reflectance spectroscopy |
| url | https://www.redalyc.org/articulo.oa?id=42930202 |