Spectrophotometric determination of methyldopa in pharmaceutical formulations
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| Format: | Artículo científico |
| Sprache: | en |
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Universidade Estadual Paulista Júlio de Mesquita Filho
2005
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| _version_ | 1876472600042930176 |
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| author | P. R. S. Ribeiro |
| author_facet | P. R. S. Ribeiro |
| contents | Spectrophotometric determination of methyldopa in pharmaceutical formulations P. R. S. Ribeiro L. Pezza H. R. Pezza Química methyldopa ammonium molybdate pharmaceuticals formulations spectrophotometric determination A new, simple, precise, rapid and low-cost spectrophotometric method for methyldopadetermination in pharmaceutical preparations is described. This method is based on the complexationreaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measuredat 410 nm. Beers Law is obeyed in a concentration range of 50 200 µg ml-1 methyldopa with anexcellent correlation coefficient (r = 0.9999). No interference was observed from common excipients informulations. The results show a simple, accurate, fast and readily applied method to the determination ofmethyldopa in pharmaceutical products. The analytical results obtained for these products by the proposedmethod are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level. 2005 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42930303 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.3 Vol.30 |
| format | Artículo científico |
| id | redalyc_42930303 |
| institution | Redalyc |
| language | en |
| publishDate | 2005 |
| publisher | Universidade Estadual Paulista Júlio de Mesquita Filho |
| spellingShingle | Spectrophotometric determination of methyldopa in pharmaceutical formulations P. R. S. Ribeiro Química methyldopa ammonium molybdate pharmaceuticals formulations spectrophotometric determination Spectrophotometric determination of methyldopa in pharmaceutical formulations P. R. S. Ribeiro L. Pezza H. R. Pezza Química methyldopa ammonium molybdate pharmaceuticals formulations spectrophotometric determination A new, simple, precise, rapid and low-cost spectrophotometric method for methyldopadetermination in pharmaceutical preparations is described. This method is based on the complexationreaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measuredat 410 nm. Beers Law is obeyed in a concentration range of 50 200 µg ml-1 methyldopa with anexcellent correlation coefficient (r = 0.9999). No interference was observed from common excipients informulations. The results show a simple, accurate, fast and readily applied method to the determination ofmethyldopa in pharmaceutical products. The analytical results obtained for these products by the proposedmethod are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level. 2005 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42930303 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.3 Vol.30 |
| title | Spectrophotometric determination of methyldopa in pharmaceutical formulations |
| topic | Química methyldopa ammonium molybdate pharmaceuticals formulations spectrophotometric determination |
| url | https://www.redalyc.org/articulo.oa?id=42930303 |