Sensitive spectrophotometric determination of lansoprazole in pharmaceuticals using ceric ammonium sulphate based on redox and complex formation reactions
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| Format: | Artículo científico |
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Universidade Estadual Paulista Júlio de Mesquita Filho
2006
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| _version_ | 1876459611033174016 |
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| author | K. Basavaiah |
| author_facet | K. Basavaiah |
| contents | Sensitive spectrophotometric determination of lansoprazole in pharmaceuticals using ceric ammonium sulphate based on redox and complex formation reactions K. Basavaiah U. Anilkumar R. V. Ramakrishna Química capsules spectrophotometry ceric ammonium sulphate lansoprazole determination Two simple sensitive and cost-effective spectrophotometric methods are described forthe determination of lansoprazole (LPZ) in bulk drug and in capsules using ceric ammoniumsulphate (CAS), iron (II), orthophenanthroline and thiocyanate as reagents. In both methods, anacidic solution of lansoprazole is treated with a measured excess of CAS followed by thedetermination of unreacted oxidant by two procedures involving different reaction schemes. Thefirst method involves the reduction of residual oxidant by a known amount of iron(II), and theunreacted iron(II) is complexed with orthophenanthroline at a raised pH, and the absorbance of theresulting complex measured at 510 nm (method A). In the second method, the unreacted CAS isreduced by excess of iron (II), and the resulting iron (III) is complexed with thiocyanate in the acidmedium and the absorbance of the complex measured at 470 nm (method B). In both methods, theamount CAS reacted corresponds to the amount of LPZ. In method A, the absorbance is found toincrease linearly with the concentration of LPZ where as in method B a linear decrease inabsorbance occurs. The systems obey Beers law for 2.5-30 and 2.5-25 µg mL-1 for method A andmethod B, respectively, and the corresponding molar absorptivity values are 8.1×103 and 1.5×104L mol-1cm-1 . The methods were successfully applied to the determination of LPZ in capsules andthe results tallied well with the label claim. No interference was observed from the concomitantsubstances normally added to capsules. 2006 otro 0100-4670 https://www.redalyc.org/articulo.oa?id=42931309 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.3 Vol.31 |
| format | Artículo científico |
| id | redalyc_42931309 |
| institution | Redalyc |
| language | en |
| publishDate | 2006 |
| publisher | Universidade Estadual Paulista Júlio de Mesquita Filho |
| spellingShingle | Sensitive spectrophotometric determination of lansoprazole in pharmaceuticals using ceric ammonium sulphate based on redox and complex formation reactions K. Basavaiah Química capsules spectrophotometry ceric ammonium sulphate lansoprazole determination Sensitive spectrophotometric determination of lansoprazole in pharmaceuticals using ceric ammonium sulphate based on redox and complex formation reactions K. Basavaiah U. Anilkumar R. V. Ramakrishna Química capsules spectrophotometry ceric ammonium sulphate lansoprazole determination Two simple sensitive and cost-effective spectrophotometric methods are described forthe determination of lansoprazole (LPZ) in bulk drug and in capsules using ceric ammoniumsulphate (CAS), iron (II), orthophenanthroline and thiocyanate as reagents. In both methods, anacidic solution of lansoprazole is treated with a measured excess of CAS followed by thedetermination of unreacted oxidant by two procedures involving different reaction schemes. Thefirst method involves the reduction of residual oxidant by a known amount of iron(II), and theunreacted iron(II) is complexed with orthophenanthroline at a raised pH, and the absorbance of theresulting complex measured at 510 nm (method A). In the second method, the unreacted CAS isreduced by excess of iron (II), and the resulting iron (III) is complexed with thiocyanate in the acidmedium and the absorbance of the complex measured at 470 nm (method B). In both methods, theamount CAS reacted corresponds to the amount of LPZ. In method A, the absorbance is found toincrease linearly with the concentration of LPZ where as in method B a linear decrease inabsorbance occurs. The systems obey Beers law for 2.5-30 and 2.5-25 µg mL-1 for method A andmethod B, respectively, and the corresponding molar absorptivity values are 8.1×103 and 1.5×104L mol-1cm-1 . The methods were successfully applied to the determination of LPZ in capsules andthe results tallied well with the label claim. No interference was observed from the concomitantsubstances normally added to capsules. 2006 otro 0100-4670 https://www.redalyc.org/articulo.oa?id=42931309 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.3 Vol.31 |
| title | Sensitive spectrophotometric determination of lansoprazole in pharmaceuticals using ceric ammonium sulphate based on redox and complex formation reactions |
| topic | Química capsules spectrophotometry ceric ammonium sulphate lansoprazole determination |
| url | https://www.redalyc.org/articulo.oa?id=42931309 |