Argentimetric assay of ranitidine in bulk drug and in dosage forms
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidade Estadual Paulista Júlio de Mesquita Filho
2007
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| _version_ | 1876470889272311808 |
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| author | K. Basavaiah |
| author_facet | K. Basavaiah |
| contents | Argentimetric assay of ranitidine in bulk drug and in dosage forms K. Basavaiah B.C. Somashekar Química assay Ranitidine titrimetry silver nitrate pharmaceuticals Two simple, rapid and cost-effective methods based on titrimetric and spectrophotometric techniques are described for the assay of RNH in bulk drug and in dosage forms using silver nitrate, mercury(II)thiocyanate and iron(III)nitrate as reagents. In titrimetry, an aqueous solution of RNH is treated with measured excess of silver nitrate in HNO3 medium, followed by determination of unreacted silver nitrate by Volhard method using iron(III) alum indicator. Spectrophotometric method involve the addition a known excess of mercury(II)thiocyanate and iron(III)nitrate to RNH, followed by the measurementof the absorbance of iron(III)thiocyante complex at 470 nm. Titrimetric method is applicable over 4-30 mg range and the reaction stoichiometry is found to be 1:1 (RNH: AgNO3). In the spectrophotometricmethod, the absorbance is found to increase linearly with concentration of RNH which is corroborated by the correlation coefficient of 0.9959. The system obey Beer is law for 5-70 µg mLֿ¹. The calculated apparent molar absorptivity and sandell sensitivity values are found to be 3.27 × 103 L molֿ¹ cmֿ¹, 0.107 µg cmֿ² respectively. The limits of detection and quantification are also reported for the spectrophotometricmethod. Intra-day and inter-day precision and accuracy of the methods were evaluated as per ICHguidelines. The methods were successfully applied to the assay of RNH in formulations and the resultswere compared with those of a reference method by applying Student is t and F-tests. No interference wasobserved from common pharmaceutical excipients. The accuracy of the methods was further ascertainedby performing recovery tests by standard addition method. 2007 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42932103 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.1 Vol.32 |
| format | Artículo científico |
| id | redalyc_42932103 |
| institution | Redalyc |
| language | en |
| publishDate | 2007 |
| publisher | Universidade Estadual Paulista Júlio de Mesquita Filho |
| spellingShingle | Argentimetric assay of ranitidine in bulk drug and in dosage forms K. Basavaiah Química assay Ranitidine titrimetry silver nitrate pharmaceuticals Argentimetric assay of ranitidine in bulk drug and in dosage forms K. Basavaiah B.C. Somashekar Química assay Ranitidine titrimetry silver nitrate pharmaceuticals Two simple, rapid and cost-effective methods based on titrimetric and spectrophotometric techniques are described for the assay of RNH in bulk drug and in dosage forms using silver nitrate, mercury(II)thiocyanate and iron(III)nitrate as reagents. In titrimetry, an aqueous solution of RNH is treated with measured excess of silver nitrate in HNO3 medium, followed by determination of unreacted silver nitrate by Volhard method using iron(III) alum indicator. Spectrophotometric method involve the addition a known excess of mercury(II)thiocyanate and iron(III)nitrate to RNH, followed by the measurementof the absorbance of iron(III)thiocyante complex at 470 nm. Titrimetric method is applicable over 4-30 mg range and the reaction stoichiometry is found to be 1:1 (RNH: AgNO3). In the spectrophotometricmethod, the absorbance is found to increase linearly with concentration of RNH which is corroborated by the correlation coefficient of 0.9959. The system obey Beer is law for 5-70 µg mLֿ¹. The calculated apparent molar absorptivity and sandell sensitivity values are found to be 3.27 × 103 L molֿ¹ cmֿ¹, 0.107 µg cmֿ² respectively. The limits of detection and quantification are also reported for the spectrophotometricmethod. Intra-day and inter-day precision and accuracy of the methods were evaluated as per ICHguidelines. The methods were successfully applied to the assay of RNH in formulations and the resultswere compared with those of a reference method by applying Student is t and F-tests. No interference wasobserved from common pharmaceutical excipients. The accuracy of the methods was further ascertainedby performing recovery tests by standard addition method. 2007 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42932103 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.1 Vol.32 |
| title | Argentimetric assay of ranitidine in bulk drug and in dosage forms |
| topic | Química assay Ranitidine titrimetry silver nitrate pharmaceuticals |
| url | https://www.redalyc.org/articulo.oa?id=42932103 |