Does cotinine act upon reactive oxygen species and peroxidases?
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Universidade Estadual Paulista Júlio de Mesquita Filho
2007
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| _version_ | 1876490576971431936 |
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| author | J.C.R. Vellosa |
| author_facet | J.C.R. Vellosa |
| contents | Does cotinine act upon reactive oxygen species and peroxidases? J.C.R. Vellosa L.M. Fonseca I.L. Brunetti O.M.M.F. Oliveira N.M. Khalil Química ROS Nicotine cotinine myeloperoxidase oxidative damage Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world.It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use oftobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase andhorseradish peroxidase), we concluded that cotinine does not act directly upon H2O2, HOCl, taurinechloramines, horseradish peroxidase or myeloperoxidase. 2007 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42932109 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.1 Vol.32 |
| format | Artículo científico |
| id | redalyc_42932109 |
| institution | Redalyc |
| language | en |
| publishDate | 2007 |
| publisher | Universidade Estadual Paulista Júlio de Mesquita Filho |
| spellingShingle | Does cotinine act upon reactive oxygen species and peroxidases? J.C.R. Vellosa Química ROS Nicotine cotinine myeloperoxidase oxidative damage Does cotinine act upon reactive oxygen species and peroxidases? J.C.R. Vellosa L.M. Fonseca I.L. Brunetti O.M.M.F. Oliveira N.M. Khalil Química ROS Nicotine cotinine myeloperoxidase oxidative damage Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world.It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use oftobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase andhorseradish peroxidase), we concluded that cotinine does not act directly upon H2O2, HOCl, taurinechloramines, horseradish peroxidase or myeloperoxidase. 2007 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42932109 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.1 Vol.32 |
| title | Does cotinine act upon reactive oxygen species and peroxidases? |
| topic | Química ROS Nicotine cotinine myeloperoxidase oxidative damage |
| url | https://www.redalyc.org/articulo.oa?id=42932109 |