A criticism of the reductionist and holistic vision in the planning of drugs in biological, chemical and physical level
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Universidade Estadual Paulista Júlio de Mesquita Filho
2021
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| _version_ | 1876428314165379072 |
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| author | Daniel Augusto Barra de Oliveira |
| author_facet | Daniel Augusto Barra de Oliveira |
| contents | A criticism of the reductionist and holistic vision in the planning of drugs in biological, chemical and physical level Daniel Augusto Barra de Oliveira Edenilson dos Santos Niculau Química holism organicism Drug design reductionism systems biology In this work, two philosophical premises of science applied in the understanding of diseases and in the planning of drugs were studied. The first premise is reductionism. This idea is present in modern science when a problem can be reduced to the sum of its individual parts. Diseases can be understood as the metabolic action of few enzymes. Drugs can be planned through the mimicry of a specific enzymatic substrate. Biological molecules can be explained by the quantum theory applied to atoms and molecules. This idea has been the predominant way in modern science. On the other hand, there is a holistic view of the phenomenon. In this holistic view, the phenomenon must be understood as the whole. Drug design should be thought from a network of proteins, not just from a single enzymatic target. There is in fact a slight advantage in the reductionist method, because this philosophical view simplifies the problem. Today, a holistic view combined with methodological reductionism is used to develop new potential drugs. 2021 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42968188002 https://www.redalyc.org/journal/429/42968188002/ https://www.redalyc.org/journal/429/42968188002/html/ https://www.redalyc.org/journal/429/42968188002/42968188002.epub https://www.redalyc.org/journal/429/42968188002/movil https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.3 Vol.46 |
| format | Artículo científico |
| id | redalyc_42968188002 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Universidade Estadual Paulista Júlio de Mesquita Filho |
| spellingShingle | A criticism of the reductionist and holistic vision in the planning of drugs in biological, chemical and physical level Daniel Augusto Barra de Oliveira Química holism organicism Drug design reductionism systems biology A criticism of the reductionist and holistic vision in the planning of drugs in biological, chemical and physical level Daniel Augusto Barra de Oliveira Edenilson dos Santos Niculau Química holism organicism Drug design reductionism systems biology In this work, two philosophical premises of science applied in the understanding of diseases and in the planning of drugs were studied. The first premise is reductionism. This idea is present in modern science when a problem can be reduced to the sum of its individual parts. Diseases can be understood as the metabolic action of few enzymes. Drugs can be planned through the mimicry of a specific enzymatic substrate. Biological molecules can be explained by the quantum theory applied to atoms and molecules. This idea has been the predominant way in modern science. On the other hand, there is a holistic view of the phenomenon. In this holistic view, the phenomenon must be understood as the whole. Drug design should be thought from a network of proteins, not just from a single enzymatic target. There is in fact a slight advantage in the reductionist method, because this philosophical view simplifies the problem. Today, a holistic view combined with methodological reductionism is used to develop new potential drugs. 2021 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42968188002 https://www.redalyc.org/journal/429/42968188002/ https://www.redalyc.org/journal/429/42968188002/html/ https://www.redalyc.org/journal/429/42968188002/42968188002.epub https://www.redalyc.org/journal/429/42968188002/movil https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.3 Vol.46 |
| title | A criticism of the reductionist and holistic vision in the planning of drugs in biological, chemical and physical level |
| topic | Química holism organicism Drug design reductionism systems biology |
| url | https://www.redalyc.org/articulo.oa?id=42968188002 https://www.redalyc.org/journal/429/42968188002/ https://www.redalyc.org/journal/429/42968188002/html/ https://www.redalyc.org/journal/429/42968188002/42968188002.epub https://www.redalyc.org/journal/429/42968188002/movil https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32 |