Screening of coformers for quercetin cocrystals through mechanochemical methods
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidade Estadual Paulista Júlio de Mesquita Filho
2022
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| _version_ | 1876477311190040576 |
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| author | Fayene Zeferino Ribeiro de Souza |
| author_facet | Fayene Zeferino Ribeiro de Souza |
| contents | Screening of coformers for quercetin cocrystals through mechanochemical methods Fayene Zeferino Ribeiro de Souza Amanda Cosmo de Almeida Patrícia Osorio Ferreira Richard Perosa Fernandes Flávio Junior Caires Química flavonoid nutraceutical mechanochemistry thermal analysis Cocrystallization Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an interesting approach to improve the solubility—among other properties—of this compound. In this work, cocrystallization screening was applied through neat grinding (NG) and liquid-assisted grinding (LAG), in which QUE and four cocrystal formers (benzamide, picolinamide, isonicotinamide, and pyrazinoic acid) were tested. The precursors and QUE-coformer systems were characterized using thermoanalytical techniques (TG-DTA), X-ray powder diffraction (XRPD), and Fourier transform infrared (FTIR) spectroscopy. The results showed the formation of QUE cocrystals with picolinamide and isonicotinamide coformers in a 1:1 stoichiometric ratio. Furthermore, although coformers are isomers, spectroscopic and thermal data suggest that the supramolecular synthons involved in cocrystallization are different. 2022 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42970027004 https://www.redalyc.org/journal/429/42970027004/ https://www.redalyc.org/journal/429/42970027004/html/ https://www.redalyc.org/journal/429/42970027004/42970027004.epub https://www.redalyc.org/journal/429/42970027004/movil https://doi.org/10.26850/1678-4618eqj.v47.1.2022.p64-75 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.1 Vol.47 |
| format | Artículo científico |
| id | redalyc_42970027004 |
| institution | Redalyc |
| language | en |
| publishDate | 2022 |
| publisher | Universidade Estadual Paulista Júlio de Mesquita Filho |
| spellingShingle | Screening of coformers for quercetin cocrystals through mechanochemical methods Fayene Zeferino Ribeiro de Souza Química flavonoid nutraceutical mechanochemistry thermal analysis Cocrystallization Screening of coformers for quercetin cocrystals through mechanochemical methods Fayene Zeferino Ribeiro de Souza Amanda Cosmo de Almeida Patrícia Osorio Ferreira Richard Perosa Fernandes Flávio Junior Caires Química flavonoid nutraceutical mechanochemistry thermal analysis Cocrystallization Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an interesting approach to improve the solubility—among other properties—of this compound. In this work, cocrystallization screening was applied through neat grinding (NG) and liquid-assisted grinding (LAG), in which QUE and four cocrystal formers (benzamide, picolinamide, isonicotinamide, and pyrazinoic acid) were tested. The precursors and QUE-coformer systems were characterized using thermoanalytical techniques (TG-DTA), X-ray powder diffraction (XRPD), and Fourier transform infrared (FTIR) spectroscopy. The results showed the formation of QUE cocrystals with picolinamide and isonicotinamide coformers in a 1:1 stoichiometric ratio. Furthermore, although coformers are isomers, spectroscopic and thermal data suggest that the supramolecular synthons involved in cocrystallization are different. 2022 artículo científico 0100-4670 https://www.redalyc.org/articulo.oa?id=42970027004 https://www.redalyc.org/journal/429/42970027004/ https://www.redalyc.org/journal/429/42970027004/html/ https://www.redalyc.org/journal/429/42970027004/42970027004.epub https://www.redalyc.org/journal/429/42970027004/movil https://doi.org/10.26850/1678-4618eqj.v47.1.2022.p64-75 en http://www.redalyc.org/revista.oa?id=429 Eclética Química application/pdf Universidade Estadual Paulista Júlio de Mesquita Filho Eclética Química (Brasil) Num.1 Vol.47 |
| title | Screening of coformers for quercetin cocrystals through mechanochemical methods |
| topic | Química flavonoid nutraceutical mechanochemistry thermal analysis Cocrystallization |
| url | https://www.redalyc.org/articulo.oa?id=42970027004 https://www.redalyc.org/journal/429/42970027004/ https://www.redalyc.org/journal/429/42970027004/html/ https://www.redalyc.org/journal/429/42970027004/42970027004.epub https://www.redalyc.org/journal/429/42970027004/movil https://doi.org/10.26850/1678-4618eqj.v47.1.2022.p64-75 |