Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Universidad Nacional Autónoma de México
2019
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=43265210004 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Proteus mirabilis expressing Plasmid-encoded toxin (Pet) causes urinary tract alterations Violeta K. Espinosa-Antúnez Laura E. Castrillón-Rivera María E. Vega-Memije María Teresa Valenzuela-Vargas Teresita Sainz-Espuñes Julieta Luna-Herrera Jorge I. Castañeda-Sánchez Biología Pet (Plasmid cytoskeleton encoded toxin) urinary organs Proteus mirabilis The plasmid-encoded toxin (Pet) is one of the most studied Enterobacteriaceae autotransporters produced by the enteroaggregative Escherichia coli (EAEC). It is responsible of morphological changes in enterocytes during EAEC infection. Recently, Pet was found in the genome of the Proteus mirabilis RTX339 strain [P. mirabilis (Pet+)]. P. mirabilis causes complicated urinary tract infections (UTI) in patients having urinary catheters and structural or functional abnormalities. In this study, an UTI was induced in BALB/c female mice with the P. mirabilis (Pet+) strain. Mice infected by P. mirabilis (Pet+) showed bacterial colonization in bladder and kidney, from the second up to the tenth day post-infection. Morphological changes were evidenced by histology. Multiple exfoliated rounded cells were observed in the bladder transitional epithelium, as well as, structural cell alterations in the kidney cortex. The presence of Pet into exfoliated and parenchymal cells was confirmed by confocal microscopy. Cytoskeleton alterations were observed in those sites where Pet was detected. Pet expressed by P. mirabilis (Pet+) strain, contributes to its pathogenicity, affecting urinary tissues during the course of the infection. 2019 artículo científico 1405-888X https://www.redalyc.org/articulo.oa?id=43265210004 10.22201/fesz.23958723e.2019.0.172 en http://www.redalyc.org/revista.oa?id=432 Tip Revista Especializada en Ciencias Químico-Biológicas application/pdf Universidad Nacional Autónoma de México Tip Revista Especializada en Ciencias Químico-Biológicas (México) Vol.22