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| Format: | Artículo científico |
| Language: | en |
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Universidad Nacional Autónoma de México
2021
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| Online Access: | https://www.redalyc.org/articulo.oa?id=43271644041 https://www.redalyc.org/journal/432/43271644041/ https://www.redalyc.org/journal/432/43271644041/html/ https://www.redalyc.org/journal/432/43271644041/43271644041.epub https://www.redalyc.org/journal/432/43271644041/movil |
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Table of Contents:
- Use of 13C-glucose breath test to assess treatment adherence in nutritional intervention trials Vanessa García-Rojas Jorge Maldonado-Hernández Rosalva Mora-Escobedo Georgina Izquierdo-Montalvo Mahendra P. Verma Alfonso Aragón-Aguilar Dominic Ángel-Serrato Jorge Saúl Encarnación-Fernández Eduardo San Martín-Martínez Biología org soy siir test client Objective To validate the use of the 13C-glucose breath test to assess nutritional treatment adherence.Methods A pilot study was conducted on eleven adults. A snack made of soybean/corn-starch was enriched with U-13C-glucose. The participants were divided in three groups that consumed the snack in different periods for two weeks (A=14 days, B=10 days and C=6 days). Breath samples were collected daily to analyse the δ 13C values with isotope-ratio mass spectrometry.Results AUC (area under the curve) median of δ 13C values of group A was higher than group C (p = 0.029); differences were found when combining groups, A and B medians, comparing them with group C (p = 0.038). A negative association was found between AUC δ13C values and treatment intensity (Spearman rho = -0.708; p = 0.015). A cut-off ≤ 3.78 identifies subjects with less than 70% accomplishment of the treatment with 100% specificity and 86% sensitivity.Conclusions The 13C-glucose breath test suggests a good diagnostic performance to assess treatment adherence. 2021 artículo científico 1405-888X https://www.redalyc.org/articulo.oa?id=43271644041 https://www.redalyc.org/journal/432/43271644041/ https://www.redalyc.org/journal/432/43271644041/html/ https://www.redalyc.org/journal/432/43271644041/43271644041.epub https://www.redalyc.org/journal/432/43271644041/movil 10.22201/fesz.23958723e.2021.359 en http://www.redalyc.org/revista.oa?id=432 Tip Revista Especializada en Ciencias Químico-Biológicas application/pdf Universidad Nacional Autónoma de México Tip Revista Especializada en Ciencias Químico-Biológicas (México) Vol.24