Hormone Receptors and Other Prognostic Factors in Breast Cancer in Cuba
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| Format: | Artículo científico |
| Language: | en |
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Medical Education Cooperation with Cuba
2010
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| author | Rosa Irene Álvarez Goyanes |
| author_facet | Rosa Irene Álvarez Goyanes |
| contents | Hormone Receptors and Other Prognostic Factors in Breast Cancer in Cuba Rosa Irene Álvarez Goyanes Xiomara Escobar Pérez Rolando Camacho Rodríguez Maybi Orozco López Sonia Franco Odio Leticia LLanes Fernández Martha Guerra Yi Cristina Rodríguez Padilla Medicina breast cancer Hormone receptors prognostic factors Clinical management of breast cancer, making a prognosis and deciding on treatment, currently depend on defining prognostic factors, especially hormone receptors (HR). In addition to confirming the heterogeneity of the disease, these biological parameters are indispensable tools for designing personalized treatment. In this study, 1509 tumors from Cuban women diagnosed with breast cancer were examined. Hormone receptor (HR) expression was determined and correlated with a group of prognostic factors, such as age, tumor size, histological type, nuclear grade, histological grade, number of metastatic axillary lymph nodes, and clinical stage. Estrogen receptor (ER) expression was associated with low nuclear grade and histological grade, and with smaller tumor size (p <0.05). Analysis of age at the time of diagnosis showed that ER expression was greater in patients in the group aged >50 years (p <0.05). In general, ER expression was greater in patients in earlier clinical stages (p <0.05). With regard to HR expression, 53% of tumors in this sample were ER+ and 49% were PR+. In 38% of cases, both receptors were positive and in 28% both receptors proved negative. The ER+/PR− combination was observed in 23% of cases while only 11% exhibited the ER−/PR+ combination. These findings indicate that approximately 72% of the tumors studied expressed some level of hormone dependency. This is the first report of HR expression in Cuba using immunohistochemical techniques and a representative sample of breast tumors diagnosed in different provinces around the country. 2010 artículo científico 1555-7960 https://www.redalyc.org/articulo.oa?id=437542072007 en http://www.redalyc.org/revista.oa?id=4375 MEDICC Review application/pdf Medical Education Cooperation with Cuba MEDICC Review (Estados Unidos de América) Num.1 Vol.12 |
| format | Artículo científico |
| id | redalyc_437542072007 |
| institution | Redalyc |
| language | en |
| publishDate | 2010 |
| publisher | Medical Education Cooperation with Cuba |
| spellingShingle | Hormone Receptors and Other Prognostic Factors in Breast Cancer in Cuba Rosa Irene Álvarez Goyanes Medicina breast cancer Hormone receptors prognostic factors Hormone Receptors and Other Prognostic Factors in Breast Cancer in Cuba Rosa Irene Álvarez Goyanes Xiomara Escobar Pérez Rolando Camacho Rodríguez Maybi Orozco López Sonia Franco Odio Leticia LLanes Fernández Martha Guerra Yi Cristina Rodríguez Padilla Medicina breast cancer Hormone receptors prognostic factors Clinical management of breast cancer, making a prognosis and deciding on treatment, currently depend on defining prognostic factors, especially hormone receptors (HR). In addition to confirming the heterogeneity of the disease, these biological parameters are indispensable tools for designing personalized treatment. In this study, 1509 tumors from Cuban women diagnosed with breast cancer were examined. Hormone receptor (HR) expression was determined and correlated with a group of prognostic factors, such as age, tumor size, histological type, nuclear grade, histological grade, number of metastatic axillary lymph nodes, and clinical stage. Estrogen receptor (ER) expression was associated with low nuclear grade and histological grade, and with smaller tumor size (p <0.05). Analysis of age at the time of diagnosis showed that ER expression was greater in patients in the group aged >50 years (p <0.05). In general, ER expression was greater in patients in earlier clinical stages (p <0.05). With regard to HR expression, 53% of tumors in this sample were ER+ and 49% were PR+. In 38% of cases, both receptors were positive and in 28% both receptors proved negative. The ER+/PR− combination was observed in 23% of cases while only 11% exhibited the ER−/PR+ combination. These findings indicate that approximately 72% of the tumors studied expressed some level of hormone dependency. This is the first report of HR expression in Cuba using immunohistochemical techniques and a representative sample of breast tumors diagnosed in different provinces around the country. 2010 artículo científico 1555-7960 https://www.redalyc.org/articulo.oa?id=437542072007 en http://www.redalyc.org/revista.oa?id=4375 MEDICC Review application/pdf Medical Education Cooperation with Cuba MEDICC Review (Estados Unidos de América) Num.1 Vol.12 |
| title | Hormone Receptors and Other Prognostic Factors in Breast Cancer in Cuba |
| topic | Medicina breast cancer Hormone receptors prognostic factors |
| url | https://www.redalyc.org/articulo.oa?id=437542072007 |