Evidence of Association between Type 1 Diabetes and Exposure to Enterovirus in Cuban Children and Adolescents
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Redalyc
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Medical Education Cooperation with Cuba
2013
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| _version_ | 1876426645196242944 |
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| author | Luis Sarmiento |
| author_facet | Luis Sarmiento |
| contents | Evidence of Association between Type 1 Diabetes and Exposure to Enterovirus in Cuban Children and Adolescents Luis Sarmiento Ileana Cubas-Dueñas Eduardo Cabrera-Rode Medicina Cuba insulin autoimmunity enteroviruses autoantibodies A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclu-sive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic β cells and at clinical onset, in a population with low type 1 diabetes incidence. Possi-ble pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are diffi cult to demon-strate, arguments supporting their role in type 1 diabetes patho-genesis should not be ignored; and confi rmation could contribute to development of more effective preventive strategies. 2013 artículo científico 1555-7960 https://www.redalyc.org/articulo.oa?id=437542091007 en http://www.redalyc.org/revista.oa?id=4375 MEDICC Review application/pdf Medical Education Cooperation with Cuba MEDICC Review (Estados Unidos de América) Num.1 Vol.15 |
| format | Artículo científico |
| id | redalyc_437542091007 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Medical Education Cooperation with Cuba |
| spellingShingle | Evidence of Association between Type 1 Diabetes and Exposure to Enterovirus in Cuban Children and Adolescents Luis Sarmiento Medicina Cuba insulin autoimmunity enteroviruses autoantibodies Evidence of Association between Type 1 Diabetes and Exposure to Enterovirus in Cuban Children and Adolescents Luis Sarmiento Ileana Cubas-Dueñas Eduardo Cabrera-Rode Medicina Cuba insulin autoimmunity enteroviruses autoantibodies A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclu-sive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic β cells and at clinical onset, in a population with low type 1 diabetes incidence. Possi-ble pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are diffi cult to demon-strate, arguments supporting their role in type 1 diabetes patho-genesis should not be ignored; and confi rmation could contribute to development of more effective preventive strategies. 2013 artículo científico 1555-7960 https://www.redalyc.org/articulo.oa?id=437542091007 en http://www.redalyc.org/revista.oa?id=4375 MEDICC Review application/pdf Medical Education Cooperation with Cuba MEDICC Review (Estados Unidos de América) Num.1 Vol.15 |
| title | Evidence of Association between Type 1 Diabetes and Exposure to Enterovirus in Cuban Children and Adolescents |
| topic | Medicina Cuba insulin autoimmunity enteroviruses autoantibodies |
| url | https://www.redalyc.org/articulo.oa?id=437542091007 |