Oxidative Stress and Birth Defects in Infants of Women with Pregestational Diabetes
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Redalyc
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| Format: | Artículo científico |
| Sprache: | en |
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Medical Education Cooperation with Cuba
2013
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| _version_ | 1876446515331858432 |
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| author | Sonia Clapés |
| author_facet | Sonia Clapés |
| contents | Oxidative Stress and Birth Defects in Infants of Women with Pregestational Diabetes Sonia Clapés Tammy Fernández Gipsis Suárez Medicina Cuba hyperglycemia birth defects gene expression oxidative stress Hyperglycemia characteristic of diabetes mellitus triggers patho-logical processes in fetal development of various structures such as the retina, peripheral nerves, renal glomerulus, and arterial and venous beds. Women with diabetes prior to conception have children with birth defects three to fi ve times more frequently than women without diabetes. There is no specifi c pattern of birth defects, but the central nervous and cardiovascular systems are the most affected. Hyperglycemia leads to mitochrondrial super-oxide radical production, which activates fi ve metabolic pathways that mediate damage leading to diabetic embryopathy. Once oxi-dative stress is established, there is modifi cation of gene expres-sion controlling embryonic development in critical periods. Vitamin E application in animal models has greatly lowered occurrence of birth defects in embryonic and fetal stages, consistent with an etiologic role for oxidative stress in dysmorphogenesis. Effective metabolic control before and during pregnancy, achieved in Cuba by implementing programs for control of birth defects in children of diabetic pregnant women, has been found effective. 2013 artículo científico 1555-7960 https://www.redalyc.org/articulo.oa?id=437542091009 en http://www.redalyc.org/revista.oa?id=4375 MEDICC Review application/pdf Medical Education Cooperation with Cuba MEDICC Review (Estados Unidos de América) Num.1 Vol.15 |
| format | Artículo científico |
| id | redalyc_437542091009 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Medical Education Cooperation with Cuba |
| spellingShingle | Oxidative Stress and Birth Defects in Infants of Women with Pregestational Diabetes Sonia Clapés Medicina Cuba hyperglycemia birth defects gene expression oxidative stress Oxidative Stress and Birth Defects in Infants of Women with Pregestational Diabetes Sonia Clapés Tammy Fernández Gipsis Suárez Medicina Cuba hyperglycemia birth defects gene expression oxidative stress Hyperglycemia characteristic of diabetes mellitus triggers patho-logical processes in fetal development of various structures such as the retina, peripheral nerves, renal glomerulus, and arterial and venous beds. Women with diabetes prior to conception have children with birth defects three to fi ve times more frequently than women without diabetes. There is no specifi c pattern of birth defects, but the central nervous and cardiovascular systems are the most affected. Hyperglycemia leads to mitochrondrial super-oxide radical production, which activates fi ve metabolic pathways that mediate damage leading to diabetic embryopathy. Once oxi-dative stress is established, there is modifi cation of gene expres-sion controlling embryonic development in critical periods. Vitamin E application in animal models has greatly lowered occurrence of birth defects in embryonic and fetal stages, consistent with an etiologic role for oxidative stress in dysmorphogenesis. Effective metabolic control before and during pregnancy, achieved in Cuba by implementing programs for control of birth defects in children of diabetic pregnant women, has been found effective. 2013 artículo científico 1555-7960 https://www.redalyc.org/articulo.oa?id=437542091009 en http://www.redalyc.org/revista.oa?id=4375 MEDICC Review application/pdf Medical Education Cooperation with Cuba MEDICC Review (Estados Unidos de América) Num.1 Vol.15 |
| title | Oxidative Stress and Birth Defects in Infants of Women with Pregestational Diabetes |
| topic | Medicina Cuba hyperglycemia birth defects gene expression oxidative stress |
| url | https://www.redalyc.org/articulo.oa?id=437542091009 |