Biomodulina T May Restore Immunity in Older Adults
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| Natura: | Artículo científico |
| Lingua: | en |
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Medical Education Cooperation with Cuba
2020
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| author | Gisela María Suárez-Formigo |
| author_facet | Gisela María Suárez-Formigo |
| contents | Biomodulina T May Restore Immunity in Older Adults Gisela María Suárez-Formigo Danay Saavedra-Hernández Medicina Cuba aging immunotherapy Immunosenescence immunomodulation Worldwide, there has been a progressive demographic shift over the past 50 years resulting in a larger proportion of older adults in the general population. Aging itself is a complex biological phenomenon characterized in part by changes in the immune system known as “immunosenescence”, which makes older adults more susceptible to infectious, cardiovascular and autoimmune diseases, as well as cancers. Several strategies have been proposed in an attempt to reverse immunosenescence, including use of hormones, cytokines and thymic factors. A promising drug in the search to restore the thymic microenvironment (which plays an important role in the regulation and maintenance of the immune system) in older adults is Biomodulina T, a Cuban product registered for use in patients with recurrent respiratory infections. The administration of Biomodulina T increases the number of naïve T-lymphocyte, CD4-positive cells that have recently migrated from the thymus gland (recent thymic emigrants) and memory CD8-positive T lymphocytes, which have characteristics akin to stem cells (stem cell-like memory). Furthermore, the expression of programmed cell death 1 protein in CD4-positive T lymphocytes and CD4-positive T lymphocytes decreases, and the proliferative capacity of CD4-positive T lymphocytes increases, without changes in the frequency of regulatory T lymphocytes. These results suggest that the administration of Biomodulina T could be used to restore immunity in older adults and in other immunocompromised individuals, improve response to other immunotherapies in cancer patients, and increase the efficacy of vaccinations in older adults. Its use has been approved in Cuba for immune system restoration. 2020 otro 1555-7960 https://www.redalyc.org/articulo.oa?id=437567141011 https://www.redalyc.org/journal/4375/437567141011/ https://www.redalyc.org/journal/4375/437567141011/html/ https://www.redalyc.org/journal/4375/437567141011/437567141011.epub https://www.redalyc.org/journal/4375/437567141011/movil https://doi.org/10.37757/MR2020.V22.N3.11 en http://www.redalyc.org/revista.oa?id=4375 MEDICC Review application/pdf Medical Education Cooperation with Cuba MEDICC Review (Estados Unidos de América) Num.3 Vol.22 |
| format | Artículo científico |
| id | redalyc_437567141011 |
| language | en |
| publishDate | 2020 |
| publisher | Medical Education Cooperation with Cuba |
| spellingShingle | Biomodulina T May Restore Immunity in Older Adults Gisela María Suárez-Formigo Medicina Cuba aging immunotherapy Immunosenescence immunomodulation Biomodulina T May Restore Immunity in Older Adults Gisela María Suárez-Formigo Danay Saavedra-Hernández Medicina Cuba aging immunotherapy Immunosenescence immunomodulation Worldwide, there has been a progressive demographic shift over the past 50 years resulting in a larger proportion of older adults in the general population. Aging itself is a complex biological phenomenon characterized in part by changes in the immune system known as “immunosenescence”, which makes older adults more susceptible to infectious, cardiovascular and autoimmune diseases, as well as cancers. Several strategies have been proposed in an attempt to reverse immunosenescence, including use of hormones, cytokines and thymic factors. A promising drug in the search to restore the thymic microenvironment (which plays an important role in the regulation and maintenance of the immune system) in older adults is Biomodulina T, a Cuban product registered for use in patients with recurrent respiratory infections. The administration of Biomodulina T increases the number of naïve T-lymphocyte, CD4-positive cells that have recently migrated from the thymus gland (recent thymic emigrants) and memory CD8-positive T lymphocytes, which have characteristics akin to stem cells (stem cell-like memory). Furthermore, the expression of programmed cell death 1 protein in CD4-positive T lymphocytes and CD4-positive T lymphocytes decreases, and the proliferative capacity of CD4-positive T lymphocytes increases, without changes in the frequency of regulatory T lymphocytes. These results suggest that the administration of Biomodulina T could be used to restore immunity in older adults and in other immunocompromised individuals, improve response to other immunotherapies in cancer patients, and increase the efficacy of vaccinations in older adults. Its use has been approved in Cuba for immune system restoration. 2020 otro 1555-7960 https://www.redalyc.org/articulo.oa?id=437567141011 https://www.redalyc.org/journal/4375/437567141011/ https://www.redalyc.org/journal/4375/437567141011/html/ https://www.redalyc.org/journal/4375/437567141011/437567141011.epub https://www.redalyc.org/journal/4375/437567141011/movil https://doi.org/10.37757/MR2020.V22.N3.11 en http://www.redalyc.org/revista.oa?id=4375 MEDICC Review application/pdf Medical Education Cooperation with Cuba MEDICC Review (Estados Unidos de América) Num.3 Vol.22 |
| title | Biomodulina T May Restore Immunity in Older Adults |
| topic | Medicina Cuba aging immunotherapy Immunosenescence immunomodulation |
| url | https://www.redalyc.org/articulo.oa?id=437567141011 https://www.redalyc.org/journal/4375/437567141011/ https://www.redalyc.org/journal/4375/437567141011/html/ https://www.redalyc.org/journal/4375/437567141011/437567141011.epub https://www.redalyc.org/journal/4375/437567141011/movil https://doi.org/10.37757/MR2020.V22.N3.11 |