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| Format: | Artículo científico |
| Sprache: | en |
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Medical Education Cooperation with Cuba
2018
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| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=437577133005 |
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- Liver Stiffness Reference Values for Healthy Cuban Adults Ángela Elvírez-Gutiérrez Marlén I. Castellanos-Fernández Wendy Santillán-López Zaily Dorta-Guridi Enrique Galbán-García Enrique Arús-Soler Medicina Cuba elastography Liver disease liver fi brosis sonoelastography INTRODUCTION Reference values for liver stiffness for healthy individuals vary worldwide. Different optimal cutoff values correspond to the stages of fi brosis in chronic liver disease. OBJECTIVES Characterize the distribution of liver stiffness in Cuban adults without liver disease and its association with age, serum uric acid and body mass index. METHODS A cross-sectional study was performed of 110 plasma donors recruited from the Havana Province Blood Bank January 2016 through February 2017. Measurements of liver stiffness were performed using a FibroScan elastography device on the same day of laboratory analyses and abdominal ultrasound. The Pearson coeffi cient was used to assess correlations, and the reference range was calculated using the mean and its 95% confi dence interval. RESULTS Liver stiffness values observed ranged from 2.2–6.3 kPa. The reference range (95% CI) for the 110 subjects without known liver disease was 4.2–4.6 kPa (mean 4.4). A positive correlation was observed between liver stiffness measurements and body mass index (r = 0.255, p <0.01) and serum uric acid (r = 0.266, p <0.01). There was no correlation between liver stiffness and age. Liver stiffness in women was similar to that of men, 4.3 (2.4–6.1) and 4.5 (2.2–6.3) kPa, respectively (p = 0.086). CONCLUSIONS Liver stiffness in Cuban adults without liver disease ranges from 2.2–6.3 kPa. The reference range is 4.2–4.6 kPa. Body mass index and serum uric acid levels are positively associated with liver stiffness. 2018 artículo científico 1555-7960 https://www.redalyc.org/articulo.oa?id=437577133005 en http://www.redalyc.org/revista.oa?id=4375 MEDICC Review application/pdf Medical Education Cooperation with Cuba MEDICC Review (Estados Unidos de América) Num.1 Vol.20