Is intralesional treatment of cutaneous leishmaniasis safe against the risk of mucosal complications?
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| Format: | Artículo científico |
| Language: | en |
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Universidad Mayor de San Simón
2020
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| _version_ | 1876456240347873280 |
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| author | Jhonny Wilson Limachi-Choque |
| author_facet | Jhonny Wilson Limachi-Choque |
| contents | Is intralesional treatment of cutaneous leishmaniasis safe against the risk of mucosal complications? Jhonny Wilson Limachi-Choque Ernesto Rojas-Cabrera Aleida Verduguez-Orellana Daniel Eid-Rodríguez Medicina treatment safety systemic treatment Mucosal leishmaniasis intralesional treatment Transitional zone cancer represents 20-25% of the cases ( in radical prostatectomy specimens), its diagnosis is frequently incidental, being clinically identified as presumed adenomas. Objetive: to determine the incidence of adenocarcinoma in the transitional zone of the prostate and identify precancerous stages in patients with clinical BPH. Methods: retrospective longitudinal study from 2013-2018 in the city of Cochabamba-Bolivia; study population: patients submitted to simple, retropubic and/or transvesical prostatectomy. Data collection: based on medical records, patients with clinical symptoms of benign prostatic hyperplasia and total PSA < 4ng/ml. Results: 76 patients were identified, of which 5 were found to have Adenocarcinoma and 9 with: High Grade Prostatic Intraepithelial Neoplasia 2.6%, Atypical small acinar proliferation 7.9%, thus representing 10.5%. As for invasion, 5.3% represented perineal invasion, 2.6% lymphovascular invasion and none with extravascular invasion. Discussion: patients with transitional zone prostate cancer, present a high prostate specific antigen suspicious to adenocarcinoma. However, this study found high-risk prostate adenocarcinoma with total prostate specific antigen less than 4 ng/ml. In spite of the clinical instruments and indications for surgical therapy of a presumed benign prostatic hyperplasia, the incidence of Adenocarcinoma in the Transitional Zone was 6.5%, with a 10.5% incidence of precancerous forms, and 17.1% of the patients were at risk of lethality from the disease. 2020 artículo científico 1012-2966 https://www.redalyc.org/articulo.oa?id=445674690013 https://www.redalyc.org/journal/4456/445674690013/ https://www.redalyc.org/journal/4456/445674690013/html/ https://www.redalyc.org/journal/4456/445674690013/445674690013.epub https://www.redalyc.org/journal/4456/445674690013/movil https://doi.org/10.47993/gmb.v43i1.13 en http://www.redalyc.org/revista.oa?id=4456 Gaceta Médica Boliviana application/pdf Universidad Mayor de San Simón Gaceta Médica Boliviana (Estado Plurinacional de Bolivia) Num.1 Vol.43 |
| format | Artículo científico |
| id | redalyc_445674690013 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Universidad Mayor de San Simón |
| spellingShingle | Is intralesional treatment of cutaneous leishmaniasis safe against the risk of mucosal complications? Jhonny Wilson Limachi-Choque Medicina treatment safety systemic treatment Mucosal leishmaniasis intralesional treatment Is intralesional treatment of cutaneous leishmaniasis safe against the risk of mucosal complications? Jhonny Wilson Limachi-Choque Ernesto Rojas-Cabrera Aleida Verduguez-Orellana Daniel Eid-Rodríguez Medicina treatment safety systemic treatment Mucosal leishmaniasis intralesional treatment Transitional zone cancer represents 20-25% of the cases ( in radical prostatectomy specimens), its diagnosis is frequently incidental, being clinically identified as presumed adenomas. Objetive: to determine the incidence of adenocarcinoma in the transitional zone of the prostate and identify precancerous stages in patients with clinical BPH. Methods: retrospective longitudinal study from 2013-2018 in the city of Cochabamba-Bolivia; study population: patients submitted to simple, retropubic and/or transvesical prostatectomy. Data collection: based on medical records, patients with clinical symptoms of benign prostatic hyperplasia and total PSA < 4ng/ml. Results: 76 patients were identified, of which 5 were found to have Adenocarcinoma and 9 with: High Grade Prostatic Intraepithelial Neoplasia 2.6%, Atypical small acinar proliferation 7.9%, thus representing 10.5%. As for invasion, 5.3% represented perineal invasion, 2.6% lymphovascular invasion and none with extravascular invasion. Discussion: patients with transitional zone prostate cancer, present a high prostate specific antigen suspicious to adenocarcinoma. However, this study found high-risk prostate adenocarcinoma with total prostate specific antigen less than 4 ng/ml. In spite of the clinical instruments and indications for surgical therapy of a presumed benign prostatic hyperplasia, the incidence of Adenocarcinoma in the Transitional Zone was 6.5%, with a 10.5% incidence of precancerous forms, and 17.1% of the patients were at risk of lethality from the disease. 2020 artículo científico 1012-2966 https://www.redalyc.org/articulo.oa?id=445674690013 https://www.redalyc.org/journal/4456/445674690013/ https://www.redalyc.org/journal/4456/445674690013/html/ https://www.redalyc.org/journal/4456/445674690013/445674690013.epub https://www.redalyc.org/journal/4456/445674690013/movil https://doi.org/10.47993/gmb.v43i1.13 en http://www.redalyc.org/revista.oa?id=4456 Gaceta Médica Boliviana application/pdf Universidad Mayor de San Simón Gaceta Médica Boliviana (Estado Plurinacional de Bolivia) Num.1 Vol.43 |
| title | Is intralesional treatment of cutaneous leishmaniasis safe against the risk of mucosal complications? |
| topic | Medicina treatment safety systemic treatment Mucosal leishmaniasis intralesional treatment |
| url | https://www.redalyc.org/articulo.oa?id=445674690013 https://www.redalyc.org/journal/4456/445674690013/ https://www.redalyc.org/journal/4456/445674690013/html/ https://www.redalyc.org/journal/4456/445674690013/445674690013.epub https://www.redalyc.org/journal/4456/445674690013/movil https://doi.org/10.47993/gmb.v43i1.13 |