Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica
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| Format: | Artículo científico |
| Language: | en |
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Universidad de Costa Rica
2006
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| author | Lizbeth Salazar-Sánchez |
| author_facet | Lizbeth Salazar-Sánchez |
| contents | Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica Lizbeth Salazar-Sánchez Lilliana Chaves Mayra Cartin Gudrun Schuster Karin Wulff Winnie Schröder Falko H. Herrmann Biología Latin American fibrinogen polymorphisms Arterial thrombosis Eight common polymorphisms of known myocardial infarction (MI)risk factors (factor V Leiden (FVL), factor V HR2 (FVHR2), factor II 20210G>A (FII), factor VII IVS7 (FVII IVS7), factor VII Arg353Gln (FVII), factor XIII Val34Leu (FXIII), Methylenetetrahydrofolate reductase C677T (MTHFR), Angiotensin Converting Enzyme (ACE))and environmental risk factors were analyzed in a MI patients of Costa Rica.This case-control study included 186 MI subjects,95 of them <45 years and 201 age and sex matched controls.With the use of PCR method the polymorphisms were detected and through interviews additional information was collected. Hypercholesterolemia and smoking were associated with a significant risk in younger patients. High fibrinogen level was an important risk factor and interaction with smoking was detected.Mainly,the genotype 34LeuLeu of FXIII showed significant protective effect, (OR 0.32,95%CI 0.13-0.80)while the other polymorphisms showed no significant difference between the cases and the controls.Carriers of FVII (OR 2.75,95%CI 1.07-7.02) and FXIII (OR 4.20,95%CI 2.03-8.67) polymorphisms showed interaction with fibrinogen in the sta- tistical analysis. It was concluded that there was an important interaction between the common risk factors and the polymorphisms (FVII;FXIII) in the development of MI.This is one of the first reports in a Latin-American population dealing with these molecular markers and MI. 2006 artículo científico 0034-7744 https://www.redalyc.org/articulo.oa?id=44920186001 en http://www.redalyc.org/revista.oa?id=449 Revista de Biología Tropical application/pdf Universidad de Costa Rica Revista de Biología Tropical (Costa Rica) Num.1 Vol.54 |
| format | Artículo científico |
| id | redalyc_44920186001 |
| institution | Redalyc |
| language | en |
| publishDate | 2006 |
| publisher | Universidad de Costa Rica |
| spellingShingle | Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica Lizbeth Salazar-Sánchez Biología Latin American fibrinogen polymorphisms Arterial thrombosis Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica Lizbeth Salazar-Sánchez Lilliana Chaves Mayra Cartin Gudrun Schuster Karin Wulff Winnie Schröder Falko H. Herrmann Biología Latin American fibrinogen polymorphisms Arterial thrombosis Eight common polymorphisms of known myocardial infarction (MI)risk factors (factor V Leiden (FVL), factor V HR2 (FVHR2), factor II 20210G>A (FII), factor VII IVS7 (FVII IVS7), factor VII Arg353Gln (FVII), factor XIII Val34Leu (FXIII), Methylenetetrahydrofolate reductase C677T (MTHFR), Angiotensin Converting Enzyme (ACE))and environmental risk factors were analyzed in a MI patients of Costa Rica.This case-control study included 186 MI subjects,95 of them <45 years and 201 age and sex matched controls.With the use of PCR method the polymorphisms were detected and through interviews additional information was collected. Hypercholesterolemia and smoking were associated with a significant risk in younger patients. High fibrinogen level was an important risk factor and interaction with smoking was detected.Mainly,the genotype 34LeuLeu of FXIII showed significant protective effect, (OR 0.32,95%CI 0.13-0.80)while the other polymorphisms showed no significant difference between the cases and the controls.Carriers of FVII (OR 2.75,95%CI 1.07-7.02) and FXIII (OR 4.20,95%CI 2.03-8.67) polymorphisms showed interaction with fibrinogen in the sta- tistical analysis. It was concluded that there was an important interaction between the common risk factors and the polymorphisms (FVII;FXIII) in the development of MI.This is one of the first reports in a Latin-American population dealing with these molecular markers and MI. 2006 artículo científico 0034-7744 https://www.redalyc.org/articulo.oa?id=44920186001 en http://www.redalyc.org/revista.oa?id=449 Revista de Biología Tropical application/pdf Universidad de Costa Rica Revista de Biología Tropical (Costa Rica) Num.1 Vol.54 |
| title | Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica |
| topic | Biología Latin American fibrinogen polymorphisms Arterial thrombosis |
| url | https://www.redalyc.org/articulo.oa?id=44920186001 |