Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico
Fuente:
Redalyc
Salvato in:
| Autore principale: | |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Universidad de Costa Rica
2017
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1876479980673695744 |
|---|---|
| author | Álvaro Segura |
| author_facet | Álvaro Segura |
| contents | Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico Álvaro Segura María Herrera Mariángela Vargas Mauren Villalta Alfredo Uscanga-Reynell Guillermo León José María Gutiérrez Biología Bothrops Crotalus antivenom Snake venom neutralization The assessment of the preclinical neutralizing ability of antivenoms in Latin America is necessary to determine their scope of efficacy . This study was aimed at analyzing the neutralizing efficacy of a polyspecific bothropic-crotalic antivenom manufactured by BIRMEX in Mexico against lethal, hemorrhagic, defibrinogenat - ing and in vitro coagulant activities of the venoms of Bothrops jararaca (Brazil), B. atrox (Perú and Colombia), B. diporus (Argentina), B. mattogrossensis (Bolivia), and B. asper (Costa Rica). Standard laboratory tests to determine these activities were used. In agreement with previous studies with bothropic antivenoms in Latin America, a pattern of cross-neutralization of heterologous venoms was observed. However, the antivenom had low neutralizing potency against defibrinogenating effect of the venoms of B. atrox (Colombia) and B. asper (Costa Rica), and failed to neutralize the in vitro coagulant activity of the venom of B. asper (Costa Rica) at the highest antivenom/venom ratio tested. It is concluded that, with the exception of coagulant and defibrinogenat - ing activities of B. asper (Costa Rica) venom, this antivenom neutralizes toxic effects of various Bothrops sp venoms. Future studies are necessary to assess the efficacy of this antivenom against other viperid venoms. Rev. Biol. Trop. 65 (1): 345-350. Epub 2017 March 01. 2017 artículo científico 0034-7744 https://www.redalyc.org/articulo.oa?id=44950154027 https://www.redalyc.org/journal/449/44950154027/ https://www.redalyc.org/journal/449/44950154027/html/ https://www.redalyc.org/journal/449/44950154027/44950154027.epub https://www.redalyc.org/journal/449/44950154027/movil en http://www.redalyc.org/revista.oa?id=449 Revista de Biología Tropical application/pdf Universidad de Costa Rica Revista de Biología Tropical (Costa Rica) Num.1 Vol.65 |
| format | Artículo científico |
| id | redalyc_44950154027 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Universidad de Costa Rica |
| spellingShingle | Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico Álvaro Segura Biología Bothrops Crotalus antivenom Snake venom neutralization Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico Álvaro Segura María Herrera Mariángela Vargas Mauren Villalta Alfredo Uscanga-Reynell Guillermo León José María Gutiérrez Biología Bothrops Crotalus antivenom Snake venom neutralization The assessment of the preclinical neutralizing ability of antivenoms in Latin America is necessary to determine their scope of efficacy . This study was aimed at analyzing the neutralizing efficacy of a polyspecific bothropic-crotalic antivenom manufactured by BIRMEX in Mexico against lethal, hemorrhagic, defibrinogenat - ing and in vitro coagulant activities of the venoms of Bothrops jararaca (Brazil), B. atrox (Perú and Colombia), B. diporus (Argentina), B. mattogrossensis (Bolivia), and B. asper (Costa Rica). Standard laboratory tests to determine these activities were used. In agreement with previous studies with bothropic antivenoms in Latin America, a pattern of cross-neutralization of heterologous venoms was observed. However, the antivenom had low neutralizing potency against defibrinogenating effect of the venoms of B. atrox (Colombia) and B. asper (Costa Rica), and failed to neutralize the in vitro coagulant activity of the venom of B. asper (Costa Rica) at the highest antivenom/venom ratio tested. It is concluded that, with the exception of coagulant and defibrinogenat - ing activities of B. asper (Costa Rica) venom, this antivenom neutralizes toxic effects of various Bothrops sp venoms. Future studies are necessary to assess the efficacy of this antivenom against other viperid venoms. Rev. Biol. Trop. 65 (1): 345-350. Epub 2017 March 01. 2017 artículo científico 0034-7744 https://www.redalyc.org/articulo.oa?id=44950154027 https://www.redalyc.org/journal/449/44950154027/ https://www.redalyc.org/journal/449/44950154027/html/ https://www.redalyc.org/journal/449/44950154027/44950154027.epub https://www.redalyc.org/journal/449/44950154027/movil en http://www.redalyc.org/revista.oa?id=449 Revista de Biología Tropical application/pdf Universidad de Costa Rica Revista de Biología Tropical (Costa Rica) Num.1 Vol.65 |
| title | Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico |
| topic | Biología Bothrops Crotalus antivenom Snake venom neutralization |
| url | https://www.redalyc.org/articulo.oa?id=44950154027 https://www.redalyc.org/journal/449/44950154027/ https://www.redalyc.org/journal/449/44950154027/html/ https://www.redalyc.org/journal/449/44950154027/44950154027.epub https://www.redalyc.org/journal/449/44950154027/movil |