Relevance of the plasminogen activation system in the pathogenesis and progression of gastric cancer
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| Format: | Artículo científico |
| Langue: | en |
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Universidad de Costa Rica
2018
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| _version_ | 1876430061170589696 |
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| author | Warner Alpízar-Alpízar |
| author_facet | Warner Alpízar-Alpízar |
| contents | Relevance of the plasminogen activation system in the pathogenesis and progression of gastric cancer Warner Alpízar-Alpízar Wendy Malespín-Bendaña Clas Une Vanessa Ramírez-Mayorga Biología uPAR metástasis Cáncer gástrico sistema activador de plasminógeno Gastric cancer is ranked as the third death-causing cancer and one of the most incident malignancies worldwide. AlthoughHelicobacter pyloriis the most well-established risk factor for the development of this neoplasm, most of the infected individuals do not develop gastric cancer. Two of the main challenges faced by the world’s scientific community in the combat against gastric cancer are the unraveling of its pathogenesis and the identification of novel ways to bring down the mortality. Malignant cell invasion of the non-neoplastic adjacent tissue and metastasis are pivotal events during cancer development and progression. Both processes are facilitated by proteases capable of degrading components of the extracellular matrix, some of which have been associated to clinic-pathological aspects of the disease. Recent studies have suggested the possible connection betweenH. pyloriand the expression of some of these proteases in gastric mucosa. This review summarizes the current knowledge about epidemiological, clinical and biological aspects of gastric cancer; it also discusses the main findings about the involvement of the plasminogen activation system in the development and progression of this disease, as well as its potential repercussions in the clinical setting. Rev. Biol. Trop. 66(1): 28-47. Epub 2018 March 01. 2018 artículo científico 0034-7744 https://www.redalyc.org/articulo.oa?id=44955366003 https://www.redalyc.org/journal/449/44955366003/ https://www.redalyc.org/journal/449/44955366003/html/ https://www.redalyc.org/journal/449/44955366003/44955366003.epub https://www.redalyc.org/journal/449/44955366003/movil 10.15517/rbt.v66i1.29014 en http://www.redalyc.org/revista.oa?id=449 Revista de Biología Tropical application/pdf Universidad de Costa Rica Revista de Biología Tropical (Costa Rica) Num.1 Vol.66 |
| format | Artículo científico |
| id | redalyc_44955366003 |
| institution | Redalyc |
| language | en |
| publishDate | 2018 |
| publisher | Universidad de Costa Rica |
| spellingShingle | Relevance of the plasminogen activation system in the pathogenesis and progression of gastric cancer Warner Alpízar-Alpízar Biología uPAR metástasis Cáncer gástrico sistema activador de plasminógeno Relevance of the plasminogen activation system in the pathogenesis and progression of gastric cancer Warner Alpízar-Alpízar Wendy Malespín-Bendaña Clas Une Vanessa Ramírez-Mayorga Biología uPAR metástasis Cáncer gástrico sistema activador de plasminógeno Gastric cancer is ranked as the third death-causing cancer and one of the most incident malignancies worldwide. AlthoughHelicobacter pyloriis the most well-established risk factor for the development of this neoplasm, most of the infected individuals do not develop gastric cancer. Two of the main challenges faced by the world’s scientific community in the combat against gastric cancer are the unraveling of its pathogenesis and the identification of novel ways to bring down the mortality. Malignant cell invasion of the non-neoplastic adjacent tissue and metastasis are pivotal events during cancer development and progression. Both processes are facilitated by proteases capable of degrading components of the extracellular matrix, some of which have been associated to clinic-pathological aspects of the disease. Recent studies have suggested the possible connection betweenH. pyloriand the expression of some of these proteases in gastric mucosa. This review summarizes the current knowledge about epidemiological, clinical and biological aspects of gastric cancer; it also discusses the main findings about the involvement of the plasminogen activation system in the development and progression of this disease, as well as its potential repercussions in the clinical setting. Rev. Biol. Trop. 66(1): 28-47. Epub 2018 March 01. 2018 artículo científico 0034-7744 https://www.redalyc.org/articulo.oa?id=44955366003 https://www.redalyc.org/journal/449/44955366003/ https://www.redalyc.org/journal/449/44955366003/html/ https://www.redalyc.org/journal/449/44955366003/44955366003.epub https://www.redalyc.org/journal/449/44955366003/movil 10.15517/rbt.v66i1.29014 en http://www.redalyc.org/revista.oa?id=449 Revista de Biología Tropical application/pdf Universidad de Costa Rica Revista de Biología Tropical (Costa Rica) Num.1 Vol.66 |
| title | Relevance of the plasminogen activation system in the pathogenesis and progression of gastric cancer |
| topic | Biología uPAR metástasis Cáncer gástrico sistema activador de plasminógeno |
| url | https://www.redalyc.org/articulo.oa?id=44955366003 https://www.redalyc.org/journal/449/44955366003/ https://www.redalyc.org/journal/449/44955366003/html/ https://www.redalyc.org/journal/449/44955366003/44955366003.epub https://www.redalyc.org/journal/449/44955366003/movil |