MODELING POST-KALA-AZAR DERMAL LEISHMANIASIS AS AN INFECTION RESERVOIR FOR VISCERAL LEISHMANIASIS
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| Format: | Artículo científico |
| Langue: | en |
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Universidad de Costa Rica
2020
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| _version_ | 1876435870837374976 |
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| author | ANDREA CALDERON |
| author_facet | ANDREA CALDERON |
| contents | MODELING POST-KALA-AZAR DERMAL LEISHMANIASIS AS AN INFECTION RESERVOIR FOR VISCERAL LEISHMANIASIS ANDREA CALDERON RYAN LANDRITH NHAN LE ILEANA MUÑOZ CHRISTOPHER M. KRIBS Física, Astronomía y Matemáticas sandfly vector Disease reservoir experimental treatment Visceral Leishmaniasis (VL) is a potentially fatal disease caused by the protozoan parasite Leishmania donovani. This disease is a health problem for the very poor because it results in thousands of deaths and illnesses every year. Some countries, such as India and Bangladesh, have started programs to reduce the occurrences of VL by focusing on early diagnosis and complete treatment of VL. Post-Kala-azar Dermal Leishmaniasis (PKDL) is a cutaneous manifestation of Leishmaniasis that can occur following the incomplete treatment of VL. Diagnosis and treatment of PKDL are limited in affected regions, and PKDL has been identified as a possible reservoir for infection. This study develops a mathematical model of the relationship between the level of PKDL treatment and the incidences of VL during a given period. The results indicate a nearly linear relationship between PKDL treatment rates and the percent reduction of VL incidences. With the current treatments available and considering achievable levels of treatment, the model predicts that up to 20% of VL cases could be prevented by treating new PKDL cases. Hypothetical combined treatment initiatives including bed nets and insecticide spraying are also considered. Results suggest that the population of individuals with PKDL is certainly a significant factor in the transmission of L. donovani infection, with treatment of new cases particularly important. 2020 artículo científico 1409-2433 https://www.redalyc.org/articulo.oa?id=45379176010 en http://www.redalyc.org/revista.oa?id=453 Revista de Matemática: Teoría y Aplicaciones application/pdf Universidad de Costa Rica Revista de Matemática: Teoría y Aplicaciones (Costa Rica) Num.1 Vol.27 |
| format | Artículo científico |
| id | redalyc_45379176010 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Universidad de Costa Rica |
| spellingShingle | MODELING POST-KALA-AZAR DERMAL LEISHMANIASIS AS AN INFECTION RESERVOIR FOR VISCERAL LEISHMANIASIS ANDREA CALDERON Física, Astronomía y Matemáticas sandfly vector Disease reservoir experimental treatment MODELING POST-KALA-AZAR DERMAL LEISHMANIASIS AS AN INFECTION RESERVOIR FOR VISCERAL LEISHMANIASIS ANDREA CALDERON RYAN LANDRITH NHAN LE ILEANA MUÑOZ CHRISTOPHER M. KRIBS Física, Astronomía y Matemáticas sandfly vector Disease reservoir experimental treatment Visceral Leishmaniasis (VL) is a potentially fatal disease caused by the protozoan parasite Leishmania donovani. This disease is a health problem for the very poor because it results in thousands of deaths and illnesses every year. Some countries, such as India and Bangladesh, have started programs to reduce the occurrences of VL by focusing on early diagnosis and complete treatment of VL. Post-Kala-azar Dermal Leishmaniasis (PKDL) is a cutaneous manifestation of Leishmaniasis that can occur following the incomplete treatment of VL. Diagnosis and treatment of PKDL are limited in affected regions, and PKDL has been identified as a possible reservoir for infection. This study develops a mathematical model of the relationship between the level of PKDL treatment and the incidences of VL during a given period. The results indicate a nearly linear relationship between PKDL treatment rates and the percent reduction of VL incidences. With the current treatments available and considering achievable levels of treatment, the model predicts that up to 20% of VL cases could be prevented by treating new PKDL cases. Hypothetical combined treatment initiatives including bed nets and insecticide spraying are also considered. Results suggest that the population of individuals with PKDL is certainly a significant factor in the transmission of L. donovani infection, with treatment of new cases particularly important. 2020 artículo científico 1409-2433 https://www.redalyc.org/articulo.oa?id=45379176010 en http://www.redalyc.org/revista.oa?id=453 Revista de Matemática: Teoría y Aplicaciones application/pdf Universidad de Costa Rica Revista de Matemática: Teoría y Aplicaciones (Costa Rica) Num.1 Vol.27 |
| title | MODELING POST-KALA-AZAR DERMAL LEISHMANIASIS AS AN INFECTION RESERVOIR FOR VISCERAL LEISHMANIASIS |
| topic | Física, Astronomía y Matemáticas sandfly vector Disease reservoir experimental treatment |
| url | https://www.redalyc.org/articulo.oa?id=45379176010 |