Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Sociedade Brasileira de Física
2013
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=46427890009 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Physics and Its Interfaces with Medicinal Chemistry and Drug Design Ricardo N. Santos Adriano D. Andricopulo Física, Astronomía y Matemáticas Physics Drug design Medicinal chemistry Molecular interactions Medicinal chemistry is a multidisciplinary subject that integrates knowledge from a variety of fields of science, including, but not limited to, chemistry, biology, and physics. The area of drug design involves the cooperative work of scientists with a diverse range of backgrounds and technical skills, trying to tackle complex problems using an integration of approaches and methods. One important contribution to this field comes from physics through studies that attempt to identify and quantify the molecular interactions between small molecules (drugs) and biological targets (receptors), such as the forces that govern the interactions, the thermodynamics of the drug–receptor interactions, and so on. In this context, the interfaces of physics, medicinal chemistry, and drug design are of vital importance for the development of drugs that not only have the right chemistry but also the right intermolecular properties to interact at the macromolecular level, providing useful information about the principles and molecular mechanisms underlying the therapeutic action of drugs. This article highlights some of the most important connections between physics and medicinal chemistry in the design of new drugs. 2013 artículo científico 0103-9733 https://www.redalyc.org/articulo.oa?id=46427890009 en http://www.redalyc.org/revista.oa?id=464 Brazilian Journal of Physics application/pdf Sociedade Brasileira de Física Brazilian Journal of Physics (Brasil) Num.4 Vol.43