Study of Neutron-DNA Interaction at the IPEN BNCT Research Facility
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| Format: | Artículo científico |
| Sprache: | en |
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Sociedade Brasileira de Física
2004
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| author | A. Deppman |
| author_facet | A. Deppman |
| contents | Study of Neutron-DNA Interaction at the IPEN BNCT Research Facility A. Deppman M. R. Gual O. Rodriguez F. Guzman V.P. Likhachev Paulo R. P. Coelho P.T.D. Siqueira J. D. T. Arruda Neto Física, Astronomía y Matemáticas Our group at the Laboratorio do Acelerador Linear (IFUSP- USP) is currently developing several studies relatedto the interaction of different kinds of radiation with DNA. Initially, our plan is to study the interactionsproton-DNA, gamma-DNA and neutron-DNA. In this work we describe the most important features of theneutron-DNA study, which we plan to perform by selecting thermal, epithermal and fast neutrons. To improvethe information about radiation-DNA interaction is important in order to achieve more secure and efficient cancertreatments by using radiation therapy. Nowadays, one important technique is the boron neutrons capturetherapy, where neutrons are used to initiate a nuclear reaction at the tumor site. The effects of the neutrons onthe health tissue, however, must be better understood. The study of neutron-DNA interaction, in this scenario, isof great importance. The research facility for Boron Neutron Capture Therapy (BNCT) in the IEA-R1 Reactorof the IPEN-CNEN/SP[1] will be used for studying the neutron-induced DNA damage. At present, we are evaluatingthe characteristics of the neutron flux at the biological sample, and we are carrying out simulations of theexperimental procedure through Monte Carlos N Particle transport code system version 4C (MCNP-4C)[2] tofind the experimental conditions necessary to minimize such contamination, and also verify the effects of thosegammas on the DNA molecule. The first step is the selection of filters configurations, which will allow us toirradiate the DNA sample with thermal, epithermal and fast neutrons. We present the results of our simulations,and describe the experimental setup show the best sets of materials necessary to obtain neutron spectra fordifferent neutrons energies. 2004 artículo científico 0103-9733 https://www.redalyc.org/articulo.oa?id=46434551 en http://www.redalyc.org/revista.oa?id=464 Brazilian Journal of Physics application/pdf Sociedade Brasileira de Física Brazilian Journal of Physics (Brasil) Num.3A Vol.34 |
| format | Artículo científico |
| id | redalyc_46434551 |
| institution | Redalyc |
| language | en |
| publishDate | 2004 |
| publisher | Sociedade Brasileira de Física |
| spellingShingle | Study of Neutron-DNA Interaction at the IPEN BNCT Research Facility A. Deppman Física, Astronomía y Matemáticas Study of Neutron-DNA Interaction at the IPEN BNCT Research Facility A. Deppman M. R. Gual O. Rodriguez F. Guzman V.P. Likhachev Paulo R. P. Coelho P.T.D. Siqueira J. D. T. Arruda Neto Física, Astronomía y Matemáticas Our group at the Laboratorio do Acelerador Linear (IFUSP- USP) is currently developing several studies relatedto the interaction of different kinds of radiation with DNA. Initially, our plan is to study the interactionsproton-DNA, gamma-DNA and neutron-DNA. In this work we describe the most important features of theneutron-DNA study, which we plan to perform by selecting thermal, epithermal and fast neutrons. To improvethe information about radiation-DNA interaction is important in order to achieve more secure and efficient cancertreatments by using radiation therapy. Nowadays, one important technique is the boron neutrons capturetherapy, where neutrons are used to initiate a nuclear reaction at the tumor site. The effects of the neutrons onthe health tissue, however, must be better understood. The study of neutron-DNA interaction, in this scenario, isof great importance. The research facility for Boron Neutron Capture Therapy (BNCT) in the IEA-R1 Reactorof the IPEN-CNEN/SP[1] will be used for studying the neutron-induced DNA damage. At present, we are evaluatingthe characteristics of the neutron flux at the biological sample, and we are carrying out simulations of theexperimental procedure through Monte Carlos N Particle transport code system version 4C (MCNP-4C)[2] tofind the experimental conditions necessary to minimize such contamination, and also verify the effects of thosegammas on the DNA molecule. The first step is the selection of filters configurations, which will allow us toirradiate the DNA sample with thermal, epithermal and fast neutrons. We present the results of our simulations,and describe the experimental setup show the best sets of materials necessary to obtain neutron spectra fordifferent neutrons energies. 2004 artículo científico 0103-9733 https://www.redalyc.org/articulo.oa?id=46434551 en http://www.redalyc.org/revista.oa?id=464 Brazilian Journal of Physics application/pdf Sociedade Brasileira de Física Brazilian Journal of Physics (Brasil) Num.3A Vol.34 |
| title | Study of Neutron-DNA Interaction at the IPEN BNCT Research Facility |
| topic | Física, Astronomía y Matemáticas |
| url | https://www.redalyc.org/articulo.oa?id=46434551 |