Computational study adsorption of mercaptopurine in generation G3 and G5 PAMAM dendrimers
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| Format: | Artículo científico |
| Langue: | en |
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Universidade Federal de Santa Maria
2015
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| author | Frydon Ashrafi |
| author_facet | Frydon Ashrafi |
| contents | Computational study adsorption of mercaptopurine in generation G3 and G5 PAMAM dendrimers Frydon Ashrafi Tahereh Mahbobi Ashraf Sadat Ghasemi Estudios Ambientales PAMAM dendrimer mercaptopurine bioavailability Due to its unique properties of dendrimers as well as with high-level groups, a special ability to carry drugs. In this study compared the interaction between the two generations of poly (amidoamine) PAMAM (G3and G5) dendrimers and the drug 6-mercaptopurine (6-MP) and the drug entrapment within the structure of dendrimers the electrostatic and covalent complexation of drugs to the dendrimer surface have been studied. The use of drug-dendrimer complex enhanced drug solubility and bioavailability of the drug. 2015 artículo científico 0100-8307 https://www.redalyc.org/articulo.oa?id=467547682003 en http://www.redalyc.org/revista.oa?id=4675 Ciência e Natura application/pdf Universidade Federal de Santa Maria Ciência e Natura (Brasil) Num.6-1 Vol.37 |
| format | Artículo científico |
| id | redalyc_467547682003 |
| institution | Redalyc |
| language | en |
| publishDate | 2015 |
| publisher | Universidade Federal de Santa Maria |
| spellingShingle | Computational study adsorption of mercaptopurine in generation G3 and G5 PAMAM dendrimers Frydon Ashrafi Estudios Ambientales PAMAM dendrimer mercaptopurine bioavailability Computational study adsorption of mercaptopurine in generation G3 and G5 PAMAM dendrimers Frydon Ashrafi Tahereh Mahbobi Ashraf Sadat Ghasemi Estudios Ambientales PAMAM dendrimer mercaptopurine bioavailability Due to its unique properties of dendrimers as well as with high-level groups, a special ability to carry drugs. In this study compared the interaction between the two generations of poly (amidoamine) PAMAM (G3and G5) dendrimers and the drug 6-mercaptopurine (6-MP) and the drug entrapment within the structure of dendrimers the electrostatic and covalent complexation of drugs to the dendrimer surface have been studied. The use of drug-dendrimer complex enhanced drug solubility and bioavailability of the drug. 2015 artículo científico 0100-8307 https://www.redalyc.org/articulo.oa?id=467547682003 en http://www.redalyc.org/revista.oa?id=4675 Ciência e Natura application/pdf Universidade Federal de Santa Maria Ciência e Natura (Brasil) Num.6-1 Vol.37 |
| title | Computational study adsorption of mercaptopurine in generation G3 and G5 PAMAM dendrimers |
| topic | Estudios Ambientales PAMAM dendrimer mercaptopurine bioavailability |
| url | https://www.redalyc.org/articulo.oa?id=467547682003 |