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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Sociedad Química de México
2010
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| Accès en ligne: | https://www.redalyc.org/articulo.oa?id=47519864009 |
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Table des matières:
- Hypargyrin A, a Hemiacetalic Germacrolide from Viguiera hypargyrea (Asteraceae). Biogenetic Implications and Biological Evaluation Raquel Arellano-Martínez Guillermo Delgado Multidisciplinaria (Ciencias Naturales y Exactas) anti budlein B Asteraceae biogenesis hypargyrin A A new hemiacetalic germacrolide 6, named hypargyrin A, was isolated from the aerial parts of Viguiera hypargyrea, along with the known compounds (8R,9R)-¿-caryophyllene epoxide, entkaur- 16-en-19-oic acid (1), hispidulin (2), 8¿-epoxyangeloyloxy-14- acetoxy-tithifolin (3), 8¿-epoxyangeloyloxy-14-hydroxy-tithifolin (4) and budlein B (5). Spectroscopic analysis of 6 allowed the structural correction of a compound isolated from Blainvillea gayana. Budlein B (5) can be considered the biogenetic precursor of 6, and two pathways for its formation are proposed. Hypargyrin A (6) did not display significant anti-inflammatory activity against ear edema in mice induced by TPA, but showed cytotoxic activity against HeLa (IC50 35.1 ¿M) and Hep-2 (39.2 ¿M) human cells. 2010 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47519864009 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.2 Vol.54