Synthesis and Antithyroid Activity of Some 8- Substituted Purine Derivatives
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Química de México
2010
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| _version_ | 1876456526547255296 |
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| author | Ismat Fatima |
| author_facet | Ismat Fatima |
| contents | Synthesis and Antithyroid Activity of Some 8- Substituted Purine Derivatives Ismat Fatima Munawar A. Munawar Affia Tasneem Multidisciplinaria (Ciencias Naturales y Exactas) 1H dione purine dihydro sulfanyl Some novel as well as known derivatives of 8-sulfanyl-3,9- dihydro-1H-purine-2,6-dione were synthesized and their antithyroid activity was measured in rats after administration of a daily dose of 20mg/kg via i.p. injection for 15 days. Free thyroxine and triiodothyronine concentrations were determined using radioimmunoassay technique. The assay results showed decrease in the hormonal concentrations for the animals treated with these compounds as compared to the control animals. Similarly, thyroid stimulating hormone level was measured with ELISA method and the results demonstrated a comparative increase of this hormone for the treated animals. The hormonal variations indicated significant (¿<= .0.05) activity of the compounds. Histological study of thyroid tissues from the test animals showed cellular modifications in the treated animals like cylindrical shape of follicular epithelium, depletion of colloid and high values of thyroid body indices. All these factors further confirmed the antithyroid effects of the compounds under study. 2010 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47521542008 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.4 Vol.54 |
| format | Artículo científico |
| id | redalyc_47521542008 |
| institution | Redalyc |
| language | en |
| publishDate | 2010 |
| publisher | Sociedad Química de México |
| spellingShingle | Synthesis and Antithyroid Activity of Some 8- Substituted Purine Derivatives Ismat Fatima Multidisciplinaria (Ciencias Naturales y Exactas) 1H dione purine dihydro sulfanyl Synthesis and Antithyroid Activity of Some 8- Substituted Purine Derivatives Ismat Fatima Munawar A. Munawar Affia Tasneem Multidisciplinaria (Ciencias Naturales y Exactas) 1H dione purine dihydro sulfanyl Some novel as well as known derivatives of 8-sulfanyl-3,9- dihydro-1H-purine-2,6-dione were synthesized and their antithyroid activity was measured in rats after administration of a daily dose of 20mg/kg via i.p. injection for 15 days. Free thyroxine and triiodothyronine concentrations were determined using radioimmunoassay technique. The assay results showed decrease in the hormonal concentrations for the animals treated with these compounds as compared to the control animals. Similarly, thyroid stimulating hormone level was measured with ELISA method and the results demonstrated a comparative increase of this hormone for the treated animals. The hormonal variations indicated significant (¿<= .0.05) activity of the compounds. Histological study of thyroid tissues from the test animals showed cellular modifications in the treated animals like cylindrical shape of follicular epithelium, depletion of colloid and high values of thyroid body indices. All these factors further confirmed the antithyroid effects of the compounds under study. 2010 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47521542008 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.4 Vol.54 |
| title | Synthesis and Antithyroid Activity of Some 8- Substituted Purine Derivatives |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) 1H dione purine dihydro sulfanyl |
| url | https://www.redalyc.org/articulo.oa?id=47521542008 |