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| Format: | Artículo científico |
| Language: | en |
| Published: |
Sociedad Química de México
2013
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| Online Access: | https://www.redalyc.org/articulo.oa?id=47529964004 |
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Table of Contents:
- Spectroscopic Characterization of an Oxovanadium(IV) Complex of Oxodiacetic Acid and 2,2’-Bipyridine. Bioactivity on Osteoblast-Like Cells in Culture Ignacio E. León Susana B. Etcheverry Beatriz S. Parajón-Costa Enrique J. Baran Multidisciplinaria (Ciencias Naturales y Exactas) 2’ vi vi vi 2’ The oxovanadium(IV) complex of oxodiacetic acid (H 2 ODA) and 2,2’-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)] ⋅ H 2 O, was thoroughly characterized by infrared, Raman and electronic spec - troscopies. The biological activity of the complex on the cell prolifera - tion was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but its action was statistically stronger in the tumoral cells. This effect was specially marked with increasing concentrations of the complex. Based on these preliminary biological results, [VO(ODA)(bipy)] ⋅ H 2 O can be considered as a good candidate to be further investigated in relation to cancer treatment. 2013 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47529964004 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.3 Vol.57