New Isoniazid Complexes, Promising Agents Against Mycobacterium tuberculosis
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Química de México
2013
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| _version_ | 1876441497269698560 |
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| author | Mariana Poggi |
| author_facet | Mariana Poggi |
| contents | New Isoniazid Complexes, Promising Agents Against Mycobacterium tuberculosis Mariana Poggi Rafael Barroso Antonio José Costa-Filho Heloisa Barbosa de Barros Fernando Pavan Clarice Queico Leite Dinorah Gambino María Helvecia Torre Multidisciplinaria (Ciencias Naturales y Exactas) isoniazid isoniazid tuberculosis tuberculosis spectroscopy Tuberculosis (TB) is a public health disease that produces several million deaths annually worldwide. Due to this critical situa - tion and the appearance of drug-resistant microbial strains, innovation in TB drug discovery is a research priority. In this work, the synthesis and characterization by elemental analysis, thermogravimetry, con - ductimetric measurements and spectroscopies UV-Vis, IR and EPR of [Cu(INH)(H 2 O)]SO 4 ⋅ 2H 2 O (Cu-INH) and [CoCl(INH) 2 (H 2 O)] Cl ⋅ 2.5H 2 O (Co-INH) complexes with isoniazid (INH) are reported. Besides, the lipophilicity, the activity against Mycobacterium tuber - culosis (MIC Cu-INH = 0.78 μ g/mL and MIC Co-INH = 0.19 μ g/mL) and the cytotoxicity (IC 50 = 48.8 and 625 μ g/mL for the copper and co - balt complexes, respectively) were measured and the selectivity index (62.5 for Cu-INH and 3205 for Co-INH) was calculated. These results indicate that these complexes are good candidates for further studies. 2013 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47529964007 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.3 Vol.57 |
| format | Artículo científico |
| id | redalyc_47529964007 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Sociedad Química de México |
| spellingShingle | New Isoniazid Complexes, Promising Agents Against Mycobacterium tuberculosis Mariana Poggi Multidisciplinaria (Ciencias Naturales y Exactas) isoniazid isoniazid tuberculosis tuberculosis spectroscopy New Isoniazid Complexes, Promising Agents Against Mycobacterium tuberculosis Mariana Poggi Rafael Barroso Antonio José Costa-Filho Heloisa Barbosa de Barros Fernando Pavan Clarice Queico Leite Dinorah Gambino María Helvecia Torre Multidisciplinaria (Ciencias Naturales y Exactas) isoniazid isoniazid tuberculosis tuberculosis spectroscopy Tuberculosis (TB) is a public health disease that produces several million deaths annually worldwide. Due to this critical situa - tion and the appearance of drug-resistant microbial strains, innovation in TB drug discovery is a research priority. In this work, the synthesis and characterization by elemental analysis, thermogravimetry, con - ductimetric measurements and spectroscopies UV-Vis, IR and EPR of [Cu(INH)(H 2 O)]SO 4 ⋅ 2H 2 O (Cu-INH) and [CoCl(INH) 2 (H 2 O)] Cl ⋅ 2.5H 2 O (Co-INH) complexes with isoniazid (INH) are reported. Besides, the lipophilicity, the activity against Mycobacterium tuber - culosis (MIC Cu-INH = 0.78 μ g/mL and MIC Co-INH = 0.19 μ g/mL) and the cytotoxicity (IC 50 = 48.8 and 625 μ g/mL for the copper and co - balt complexes, respectively) were measured and the selectivity index (62.5 for Cu-INH and 3205 for Co-INH) was calculated. These results indicate that these complexes are good candidates for further studies. 2013 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47529964007 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.3 Vol.57 |
| title | New Isoniazid Complexes, Promising Agents Against Mycobacterium tuberculosis |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) isoniazid isoniazid tuberculosis tuberculosis spectroscopy |
| url | https://www.redalyc.org/articulo.oa?id=47529964007 |