A Therapeutic System of 177Lu-labeled Gold Nanoparticles-RGD Internalized in Breast Cancer Cells
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| Format: | Artículo científico |
| Langue: | en |
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Sociedad Química de México
2013
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| _version_ | 1876481969147084800 |
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| author | Myrna Luna-Gutiérrez |
| author_facet | Myrna Luna-Gutiérrez |
| contents | A Therapeutic System of 177Lu-labeled Gold Nanoparticles-RGD Internalized in Breast Cancer Cells Myrna Luna-Gutiérrez Guillermina Ferro-Flores Blanca E. Ocampo-García Clara L. Santos-Cuevas Nallely Jiménez-Mancilla L.M. De León-Rodríguez Erika Azorín-Vega Keila Isaac-Olivé Multidisciplinaria (Ciencias Naturales y Exactas) 177 tide radio peptide RGD pep The aim of this research was to evaluate the in vitro potential of 177 Lu-labeled gold nanoparticles conjugated to cyclo-[RGDfK(C)] peptides ( 177 Lu-AuNP-c[RGDfK(C)]) as a plasmonic photothermal therapy and targeted radiotherapy system in MCF7 breast cancer cells. Peptides were conjugated to AuNPs (20 nm) by spontaneous reaction with the thiol group of cysteine (C). After laser irradiation, the pres - ence of c[RGDfK(C)]-AuNP in cells caused a significant increase in the temperature of the medium (50.5 °C, compared to 40.3 °C without AuNPs) resulting in a significant decrease in MCF7 cell viability down to 9 %. After treatment with 177 Lu-AuNP-c[RGDfK(C)], the MCF7 cell proliferation was significantly inhibited. 2013 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47529964009 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.3 Vol.57 |
| format | Artículo científico |
| id | redalyc_47529964009 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Sociedad Química de México |
| spellingShingle | A Therapeutic System of 177Lu-labeled Gold Nanoparticles-RGD Internalized in Breast Cancer Cells Myrna Luna-Gutiérrez Multidisciplinaria (Ciencias Naturales y Exactas) 177 tide radio peptide RGD pep A Therapeutic System of 177Lu-labeled Gold Nanoparticles-RGD Internalized in Breast Cancer Cells Myrna Luna-Gutiérrez Guillermina Ferro-Flores Blanca E. Ocampo-García Clara L. Santos-Cuevas Nallely Jiménez-Mancilla L.M. De León-Rodríguez Erika Azorín-Vega Keila Isaac-Olivé Multidisciplinaria (Ciencias Naturales y Exactas) 177 tide radio peptide RGD pep The aim of this research was to evaluate the in vitro potential of 177 Lu-labeled gold nanoparticles conjugated to cyclo-[RGDfK(C)] peptides ( 177 Lu-AuNP-c[RGDfK(C)]) as a plasmonic photothermal therapy and targeted radiotherapy system in MCF7 breast cancer cells. Peptides were conjugated to AuNPs (20 nm) by spontaneous reaction with the thiol group of cysteine (C). After laser irradiation, the pres - ence of c[RGDfK(C)]-AuNP in cells caused a significant increase in the temperature of the medium (50.5 °C, compared to 40.3 °C without AuNPs) resulting in a significant decrease in MCF7 cell viability down to 9 %. After treatment with 177 Lu-AuNP-c[RGDfK(C)], the MCF7 cell proliferation was significantly inhibited. 2013 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47529964009 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.3 Vol.57 |
| title | A Therapeutic System of 177Lu-labeled Gold Nanoparticles-RGD Internalized in Breast Cancer Cells |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) 177 tide radio peptide RGD pep |
| url | https://www.redalyc.org/articulo.oa?id=47529964009 |