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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Sociedad Química de México
2013
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=47529964013 |
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Sommario:
- Metal-Based Drug-DNA Interactions Juan Carlos García-Ramos Rodrigo Galindo-Murillo Fernando Cortés-Guzmán Lena Ruiz-Azuara Multidisciplinaria (Ciencias Naturales y Exactas) DNA interaction antitumoral transition metals theoretical methods Coordination compounds that bind to DNA have been an active area of research since the discovery of cisplatin and the plati - num based drugs. In this review we offer a general overview about transition-metal compounds that binds DNA through several ways and some examples are given to understand the role played by the different factors that promotes it, such as the intercalant ligand and the nature and position of the substituent over it. Several techniques to follow metal-based drugs interactions with DNA are mentioned as well as a brief description of computational techniques that can be used as a powerful tool in order to reach a deep knowledge of the parameters involved in the stabilization of coordination compound-DNA adduct. 2013 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47529964013 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.3 Vol.57