Chemometrics as a Tool in the Study of Lead Toxicity in Rats
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| Format: | Artículo científico |
| Langue: | en |
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Sociedad Química de México
2015
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| author | Judith Amador-Hernández |
| author_facet | Judith Amador-Hernández |
| contents | Chemometrics as a Tool in the Study of Lead Toxicity in Rats Judith Amador-Hernández Leticia Guadalupe Navarro Moreno Miguel Velázquez Manzanares Iliana Margarita de la Garza Rodríguez Edith Madaí Colunga Urbina Mariazel Hernández Sánchez Multidisciplinaria (Ciencias Naturales y Exactas) Pb Rats Kidney Toxicity Chemometrics In this work, chemometric tools were applied to establish correlations between biomarkers for identifying the most significant ones in relation to acute exposure of Wistar rats to Pb. The metal content in biological matrices (serum, urine, liver, brain, and kidney), biochemical parameters (protein content, activity of the Glutathione S-Transferase enzymes, and urinalysis), apart from morphological measurements of organisms, were estimated in both the exposed and the control groups and submitted to Significance tests, Principal Component Analysis, Hierarchical Cluster Analysis, and Generalized Procrustean Analysis. It could be observed that Pb in serum, but not in erythrocytes, was the biomarker associated with the Pb content in kidney and other parameters related to this organ. In the same way, Pearson correlation coefficients emphasized the relation between Pb in serum and these variables, with the exception of kidney weight. Ad-ditionally, Pb in serum was found to be the biomarker with the greatest difference between the control and the exposed groups, which converts it into the most sensitive biomarker in the present study. 2015 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47539242002 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.1 Vol.59 |
| format | Artículo científico |
| id | redalyc_47539242002 |
| institution | Redalyc |
| language | en |
| publishDate | 2015 |
| publisher | Sociedad Química de México |
| spellingShingle | Chemometrics as a Tool in the Study of Lead Toxicity in Rats Judith Amador-Hernández Multidisciplinaria (Ciencias Naturales y Exactas) Pb Rats Kidney Toxicity Chemometrics Chemometrics as a Tool in the Study of Lead Toxicity in Rats Judith Amador-Hernández Leticia Guadalupe Navarro Moreno Miguel Velázquez Manzanares Iliana Margarita de la Garza Rodríguez Edith Madaí Colunga Urbina Mariazel Hernández Sánchez Multidisciplinaria (Ciencias Naturales y Exactas) Pb Rats Kidney Toxicity Chemometrics In this work, chemometric tools were applied to establish correlations between biomarkers for identifying the most significant ones in relation to acute exposure of Wistar rats to Pb. The metal content in biological matrices (serum, urine, liver, brain, and kidney), biochemical parameters (protein content, activity of the Glutathione S-Transferase enzymes, and urinalysis), apart from morphological measurements of organisms, were estimated in both the exposed and the control groups and submitted to Significance tests, Principal Component Analysis, Hierarchical Cluster Analysis, and Generalized Procrustean Analysis. It could be observed that Pb in serum, but not in erythrocytes, was the biomarker associated with the Pb content in kidney and other parameters related to this organ. In the same way, Pearson correlation coefficients emphasized the relation between Pb in serum and these variables, with the exception of kidney weight. Ad-ditionally, Pb in serum was found to be the biomarker with the greatest difference between the control and the exposed groups, which converts it into the most sensitive biomarker in the present study. 2015 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47539242002 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.1 Vol.59 |
| title | Chemometrics as a Tool in the Study of Lead Toxicity in Rats |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Pb Rats Kidney Toxicity Chemometrics |
| url | https://www.redalyc.org/articulo.oa?id=47539242002 |