Preparation of (+)- and (−)- B-phenyl- and B-(4-chlorophenyl)-y-butyrolactones: Key Intermediates in the Synthesis of B-phenyl-GABA and Baclofen.
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedad Química de México
2015
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| _version_ | 1876447396967219200 |
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| author | Jazmín Gómez-Gutiérrez |
| author_facet | Jazmín Gómez-Gutiérrez |
| contents | Preparation of (+)- and (−)- B-phenyl- and B-(4-chlorophenyl)-y-butyrolactones: Key Intermediates in the Synthesis of B-phenyl-GABA and Baclofen. Jazmín Gómez-Gutiérrez Myriam Meléndez-Rodríguez Óscar R. Suárez-Castillo Luis E. Castelán - Duarte Manuel J. Fragoso-Vázquez Erick López-Vázquez Maricruz Sánchez-Zavala Multidisciplinaria (Ciencias Naturales y Exactas) Resolution Diastereoisomeric4 hydroxybutyramides Phenylγbutyrolactones Thepreparationofβ-phenyl-andβ-(4-chlorophenyl)-γ-bu-tyrolactones( ± )-3and( ± )-4andtheirresolutiontothecorrespond-ing(+)-(S)-3, (−)-(R)-3and(+)-(S)-4, (−)-(R)-4throughformation,flashcolumnchromatographyseparationandsubsequenthydrolysisofdiastereoisomeric4-hydroxybutyramides(2’R,3S)-5,(2’R,3R)-5,(2’R,3S)-6and(2’R,3R)-6isdescribed.Theabsoluteconfigurationassignmentofenantiopure3and4wassupportedbyX-raycrystal-lographicstructuresof(2’R,3R)-5,(2’R,3S)-6and(2’R,3R)-6 2015 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47539242003 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.1 Vol.59 |
| format | Artículo científico |
| id | redalyc_47539242003 |
| institution | Redalyc |
| language | en |
| publishDate | 2015 |
| publisher | Sociedad Química de México |
| spellingShingle | Preparation of (+)- and (−)- B-phenyl- and B-(4-chlorophenyl)-y-butyrolactones: Key Intermediates in the Synthesis of B-phenyl-GABA and Baclofen. Jazmín Gómez-Gutiérrez Multidisciplinaria (Ciencias Naturales y Exactas) Resolution Diastereoisomeric4 hydroxybutyramides Phenylγbutyrolactones Preparation of (+)- and (−)- B-phenyl- and B-(4-chlorophenyl)-y-butyrolactones: Key Intermediates in the Synthesis of B-phenyl-GABA and Baclofen. Jazmín Gómez-Gutiérrez Myriam Meléndez-Rodríguez Óscar R. Suárez-Castillo Luis E. Castelán - Duarte Manuel J. Fragoso-Vázquez Erick López-Vázquez Maricruz Sánchez-Zavala Multidisciplinaria (Ciencias Naturales y Exactas) Resolution Diastereoisomeric4 hydroxybutyramides Phenylγbutyrolactones Thepreparationofβ-phenyl-andβ-(4-chlorophenyl)-γ-bu-tyrolactones( ± )-3and( ± )-4andtheirresolutiontothecorrespond-ing(+)-(S)-3, (−)-(R)-3and(+)-(S)-4, (−)-(R)-4throughformation,flashcolumnchromatographyseparationandsubsequenthydrolysisofdiastereoisomeric4-hydroxybutyramides(2’R,3S)-5,(2’R,3R)-5,(2’R,3S)-6and(2’R,3R)-6isdescribed.Theabsoluteconfigurationassignmentofenantiopure3and4wassupportedbyX-raycrystal-lographicstructuresof(2’R,3R)-5,(2’R,3S)-6and(2’R,3R)-6 2015 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47539242003 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.1 Vol.59 |
| title | Preparation of (+)- and (−)- B-phenyl- and B-(4-chlorophenyl)-y-butyrolactones: Key Intermediates in the Synthesis of B-phenyl-GABA and Baclofen. |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Resolution Diastereoisomeric4 hydroxybutyramides Phenylγbutyrolactones |
| url | https://www.redalyc.org/articulo.oa?id=47539242003 |