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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedad Química de México
2001
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=47545405 |
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| _version_ | 1866815550279122944 |
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| author | David Vargas |
| author_facet | David Vargas |
| contents | Inhibition of Phosphofructokinase by Molluscicidal Sesquiterpene Lactones David Vargas Ezzat S. Younathan Nikolaus H. Fischer Multidisciplinaria (Ciencias Naturales y Exactas) Sesquiterpene lactones molluscicidal activity phosphofructokinase inhibitors The effect of ten molluscicidal sesquiterpene lactones wastested on the enzyme phosphofructokinase (PKF) from rabbit muscle.PFK was inhibited irreversibly by all the sesquiterpene lactones tested.7a-Hydroxy-3-desoxyzaluzanin C (2) exhibited the highest efficacyof inhibition with a Ki value of 90 nM. This is also the lowest Kireported for inactivation of this enzyme by sesquiterpene lactones.The molluscicidal action of the sesquiterpene lactones tested in thisstudy correlates closely with their potency as PFK inhibitors.Preincubation of 2 with dithiothreitol resulted in loss of inhibitorypower of the lactone. The substrates adenosine-5-triphospate andfructose-6-phosphate protected phosphofructokinase against inhibitionby 2. The PFK inhibitory action and molluscicidal activity aremost significant when a hydroxyl group is in proximity of the nucleophilereceptor site, the a-methylene-g-lactone moiety. 2001 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47545405 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.4 Vol.45 |
| format | Artículo científico |
| id | redalyc_47545405 |
| language | en |
| publishDate | 2001 |
| publisher | Sociedad Química de México |
| spellingShingle | Inhibition of Phosphofructokinase by Molluscicidal Sesquiterpene Lactones David Vargas Multidisciplinaria (Ciencias Naturales y Exactas) Sesquiterpene lactones molluscicidal activity phosphofructokinase inhibitors Inhibition of Phosphofructokinase by Molluscicidal Sesquiterpene Lactones David Vargas Ezzat S. Younathan Nikolaus H. Fischer Multidisciplinaria (Ciencias Naturales y Exactas) Sesquiterpene lactones molluscicidal activity phosphofructokinase inhibitors The effect of ten molluscicidal sesquiterpene lactones wastested on the enzyme phosphofructokinase (PKF) from rabbit muscle.PFK was inhibited irreversibly by all the sesquiterpene lactones tested.7a-Hydroxy-3-desoxyzaluzanin C (2) exhibited the highest efficacyof inhibition with a Ki value of 90 nM. This is also the lowest Kireported for inactivation of this enzyme by sesquiterpene lactones.The molluscicidal action of the sesquiterpene lactones tested in thisstudy correlates closely with their potency as PFK inhibitors.Preincubation of 2 with dithiothreitol resulted in loss of inhibitorypower of the lactone. The substrates adenosine-5-triphospate andfructose-6-phosphate protected phosphofructokinase against inhibitionby 2. The PFK inhibitory action and molluscicidal activity aremost significant when a hydroxyl group is in proximity of the nucleophilereceptor site, the a-methylene-g-lactone moiety. 2001 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47545405 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.4 Vol.45 |
| title | Inhibition of Phosphofructokinase by Molluscicidal Sesquiterpene Lactones |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Sesquiterpene lactones molluscicidal activity phosphofructokinase inhibitors |
| url | https://www.redalyc.org/articulo.oa?id=47545405 |