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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Sociedad Química de México
2016
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| Acceso en línea: | https://www.redalyc.org/articulo.oa?id=47545631005 |
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- Divergent and Selective Functionalization of 2-Formylpyrrole and its Application in the Total Synthesis of the Aglycone Alkaloid Pyrrolemarumine Eder I. Martínez-Mora Miguel A. Caracas Carlos H. Escalante Damian A. Madrigal Héctor Quiroz-Florentino Francisco Delgado Joaquín Tamariz Multidisciplinaria (Ciencias Naturales y Exactas) Haac Vilsmeier formylation formylpyrrole pyrrolemarumine Diverse 1,2- and 1,2,5-substituted pyrroles were efficiently prepared through a regioselective functionalization of 2-formylpyr - role (5a). This methodology was applied for the first total synthesis of pyrrolemarumine ( 4b ), the aglycone of the corresponding natural pyr - role alkaloid 4”- O - a -L-rhamnopyranoside. The synthesis of 4b was achieved starting from 5a through a seven-step process in 28% overall yield. 2016 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47545631005 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.1 Vol.60