Two notably similar proteins follows different unfolding pathways
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Química de México
2002
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| _version_ | 1876453492291272704 |
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| author | Edgar Vázquez Contreras |
| author_facet | Edgar Vázquez Contreras |
| contents | Two notably similar proteins follows different unfolding pathways Edgar Vázquez Contreras María Elena Chánez Cárdenas Multidisciplinaria (Ciencias Naturales y Exactas) proteines fluorescence unfolding pathway Triosephosphate isomerase three dimensional structures The amino acid sequences and the three dimensional structuresof triosephosphate isomerase from the parasites Trypanosomabruceiand Trypanosoma cruzi, are markedly similar. In spite of thesestructural similarities, we found that the equilibrium unfolding pathwayof both enzymes induced by guanidinium hydrochloride is different,as showed by alterations in intrinsic fluorescence of tryptophanresidues. This behavior is possibly related with the differentreactivity that these enzymes presents against derivatizing cysteineresidues agents. 2002 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47546307 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.3 Vol.46 |
| format | Artículo científico |
| id | redalyc_47546307 |
| institution | Redalyc |
| language | en |
| publishDate | 2002 |
| publisher | Sociedad Química de México |
| spellingShingle | Two notably similar proteins follows different unfolding pathways Edgar Vázquez Contreras Multidisciplinaria (Ciencias Naturales y Exactas) proteines fluorescence unfolding pathway Triosephosphate isomerase three dimensional structures Two notably similar proteins follows different unfolding pathways Edgar Vázquez Contreras María Elena Chánez Cárdenas Multidisciplinaria (Ciencias Naturales y Exactas) proteines fluorescence unfolding pathway Triosephosphate isomerase three dimensional structures The amino acid sequences and the three dimensional structuresof triosephosphate isomerase from the parasites Trypanosomabruceiand Trypanosoma cruzi, are markedly similar. In spite of thesestructural similarities, we found that the equilibrium unfolding pathwayof both enzymes induced by guanidinium hydrochloride is different,as showed by alterations in intrinsic fluorescence of tryptophanresidues. This behavior is possibly related with the differentreactivity that these enzymes presents against derivatizing cysteineresidues agents. 2002 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47546307 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.3 Vol.46 |
| title | Two notably similar proteins follows different unfolding pathways |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) proteines fluorescence unfolding pathway Triosephosphate isomerase three dimensional structures |
| url | https://www.redalyc.org/articulo.oa?id=47546307 |