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| Format: | Artículo científico |
| Sprache: | en |
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Sociedad Química de México
2002
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| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=47546403 |
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| _version_ | 1866812451511599104 |
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| author | Noah N. Niufar |
| author_facet | Noah N. Niufar |
| contents | Reduction potentials of conjugated aliphatic ketones, oximes, and imines: correlation with structure and bioactivity Noah N. Niufar Fiona L. Haycock Jodi L. Wesemann Jason A. MacStay Victor L. Heasley Peter Kovacic Multidisciplinaria (Ciencias Naturales y Exactas) diones diimines dioximes bioactive oxidative stress To determine which structural features may favor electrontransfer in biological systems, cyclic voltammetric studies were carriedout on conjugated aliphatic ketone, oxime, and imine species atpH levels 2 through 7 in most cases. The nature of the conjugatedsubstituents strongly influenced the reduction potentials. The dionesamples were most easily reduced, followed by the diimine and thenthe mono- and di-oxime analogs. The reduction potentials for allcompounds were pH-dependent, with the most favorable potentialsoccurring at the lower pH values. The possible roles of protonation,hydrogen bonding, the captodative effect, and other aspects wereconsidered. The favorable reduction potentials of the compounds exhibitingbioactivity suggest that in vivo electron transfer and oxidativestress may be involved in various types of biological processes. 2002 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47546403 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.4 Vol.46 |
| format | Artículo científico |
| id | redalyc_47546403 |
| language | en |
| publishDate | 2002 |
| publisher | Sociedad Química de México |
| spellingShingle | Reduction potentials of conjugated aliphatic ketones, oximes, and imines: correlation with structure and bioactivity Noah N. Niufar Multidisciplinaria (Ciencias Naturales y Exactas) diones diimines dioximes bioactive oxidative stress Reduction potentials of conjugated aliphatic ketones, oximes, and imines: correlation with structure and bioactivity Noah N. Niufar Fiona L. Haycock Jodi L. Wesemann Jason A. MacStay Victor L. Heasley Peter Kovacic Multidisciplinaria (Ciencias Naturales y Exactas) diones diimines dioximes bioactive oxidative stress To determine which structural features may favor electrontransfer in biological systems, cyclic voltammetric studies were carriedout on conjugated aliphatic ketone, oxime, and imine species atpH levels 2 through 7 in most cases. The nature of the conjugatedsubstituents strongly influenced the reduction potentials. The dionesamples were most easily reduced, followed by the diimine and thenthe mono- and di-oxime analogs. The reduction potentials for allcompounds were pH-dependent, with the most favorable potentialsoccurring at the lower pH values. The possible roles of protonation,hydrogen bonding, the captodative effect, and other aspects wereconsidered. The favorable reduction potentials of the compounds exhibitingbioactivity suggest that in vivo electron transfer and oxidativestress may be involved in various types of biological processes. 2002 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47546403 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.4 Vol.46 |
| title | Reduction potentials of conjugated aliphatic ketones, oximes, and imines: correlation with structure and bioactivity |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) diones diimines dioximes bioactive oxidative stress |
| url | https://www.redalyc.org/articulo.oa?id=47546403 |