Effect of the mixing method on the sustained release profile of pelanserin from HPMC / citric acid matrix tablets
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedad Química de México
2003
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| _version_ | 1876479671528325120 |
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| author | Leopoldo Villafuerte Robles |
| author_facet | Leopoldo Villafuerte Robles |
| contents | Effect of the mixing method on the sustained release profile of pelanserin from HPMC / citric acid matrix tablets Leopoldo Villafuerte Robles Rogelio Espinoza Ramos Multidisciplinaria (Ciencias Naturales y Exactas) HPMC Pelanserin Citric acid Mixing method Sustained release Matrices obtained by wet granulation, containing variablecitric acid quantities and employing the model: Mt / Minf = k tn,showed greater release constants (kav = 0.236) and exponent n values(nav = 0.736) than those obtained by mixing in the dry (tumbling mixing),kav = 0.185 and nav = 0.606. This indicates a greater tendency toa relaxation/erosion release mechanism of wet granulation comparedto dry mixing. The results are attributed to changes in the citric aciddistribution. 2003 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47547113 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.1 Vol.47 |
| format | Artículo científico |
| id | redalyc_47547113 |
| institution | Redalyc |
| language | en |
| publishDate | 2003 |
| publisher | Sociedad Química de México |
| spellingShingle | Effect of the mixing method on the sustained release profile of pelanserin from HPMC / citric acid matrix tablets Leopoldo Villafuerte Robles Multidisciplinaria (Ciencias Naturales y Exactas) HPMC Pelanserin Citric acid Mixing method Sustained release Effect of the mixing method on the sustained release profile of pelanserin from HPMC / citric acid matrix tablets Leopoldo Villafuerte Robles Rogelio Espinoza Ramos Multidisciplinaria (Ciencias Naturales y Exactas) HPMC Pelanserin Citric acid Mixing method Sustained release Matrices obtained by wet granulation, containing variablecitric acid quantities and employing the model: Mt / Minf = k tn,showed greater release constants (kav = 0.236) and exponent n values(nav = 0.736) than those obtained by mixing in the dry (tumbling mixing),kav = 0.185 and nav = 0.606. This indicates a greater tendency toa relaxation/erosion release mechanism of wet granulation comparedto dry mixing. The results are attributed to changes in the citric aciddistribution. 2003 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47547113 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.1 Vol.47 |
| title | Effect of the mixing method on the sustained release profile of pelanserin from HPMC / citric acid matrix tablets |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) HPMC Pelanserin Citric acid Mixing method Sustained release |
| url | https://www.redalyc.org/articulo.oa?id=47547113 |