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| Format: | Artículo científico |
| Langue: | en |
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Sociedad Química de México
2003
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| Accès en ligne: | https://www.redalyc.org/articulo.oa?id=47547216 |
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Table des matières:
- Isolation and Chemical Transformations of Some Anti-inflammatory Triterpenes from Salvia mexicana L. var. minor Benth. Hortensia Parra Delgado Antonio Nieto Camacho Rosalba Argumedo Delira Ma. Teresa Ramírez Apan Mariano Martínez Vázquez Multidisciplinaria (Ciencias Naturales y Exactas) minor Triterpenos Salvia mexicana var chemical transformations antiinflamatory activity The acetone and methanol extracts of aerial parts of Salviamexicana L. var. minor showed anti-inflammatory and antioxidantproperties in the TPA y DPPH models respectively. The chromatographyof these extracts led the isolation of β-sitosterol, betulinol,betulinic acid, ursolic acid and arbutin. The presence of these triterpenesis in agreement with previos phytochemical studies of Salvia,however this is the first time that arbutin is isolated from a species ofthis genus. On the other hand, since none or the isolated compoundshowed antioxidant properties in the DPPH model, it can be inferredthat minor compounds not isolated or synergism effects couldaccount for the antioxidant properties of the extracts. It is known thatsome pentacyclic triterpene derivatives with an α,β-unsaturated carbonylin the ring A showed a better nitric oxide synthase inhibitionactivity that the natural triterpenes. It was decided to synthesize themethyl ester of 2-formyl-3-oxo-urs-28-oic and 2-formil-3-oxo-urs-1-en-28-oic acids from ursolic acid and evaluate them using the DPPHand TPA models. The results showed that both compounds have antiinflammatoryactivity, but only the 2-formyl-3-oxo-ursol-28-oic acidmethyl ester was active in DPPH assay, which is in agreement withthe proposed mechanism of this test. This is the first chemical studyof Salvia mexicana L. var. minor (Benth). 2003 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47547216 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.2 Vol.47