Synthesis and Biological Evaluation of New 3,4-diarylmaleimides as Enhancers (modulators) of Doxorubicin Cytotoxic Activity on Cultured Tumor Cells from a Real Case of Breast Cancer
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedad Química de México
2017
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| _version_ | 1876428227632693248 |
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| author | Jessica R. Gutierrez-Cano |
| author_facet | Jessica R. Gutierrez-Cano |
| contents | Synthesis and Biological Evaluation of New 3,4-diarylmaleimides as Enhancers (modulators) of Doxorubicin Cytotoxic Activity on Cultured Tumor Cells from a Real Case of Breast Cancer Jessica R. Gutierrez-Cano Pradip D. Nahide Velayudham Ramadoss Yuvraj Satkar Rafael Ortiz-Alvarado Clara Alba-Betancourt Claudia L. Mendoza-Macías César R. Solorio-Alvarado Multidisciplinaria (Ciencias Naturales y Exactas) Maleimide Doxorubicin cer treatment Breast cancer synergistic can A series of new 3,4-diarylmaleimides were synthesized in an optimized and efficient lineal sequence of three steps, starting from commercial maleimide. The biological evaluation of these compounds as enhancers (activity modulators) in the co-administration with doxo - rubicin treatment in breast cancer cells directly obtained from a pa - tient, were essayed. The cancerous tissue BT026-512N was provided by the National Institute of Cancerology (INCAN) of México. This tissue was obtained by biopsy from a patient diagnosed with stage IIB ductal breast cancer. The results obtained in the assays, show de - creased cell viability on the cultured cells for all of the maleimides synthesized in combinatorial administration with doxorubicin. The highest mortality effect was determined for maleimides 9 and 29 in - creased in close to three times the effect compared with treatment us - ing only doxorubicin. Based on previous functionalized maleimides core reports and Molinspiration chemoinformatic analysis, these re - sults could possibly point out to the Pg-p glycoprotein as bio-molecu - lar action target of maleimides by kinase phosphorylation-inhibition, although more experimental data is necessary. 2017 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47551118006 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.1 Vol.61 |
| format | Artículo científico |
| id | redalyc_47551118006 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Sociedad Química de México |
| spellingShingle | Synthesis and Biological Evaluation of New 3,4-diarylmaleimides as Enhancers (modulators) of Doxorubicin Cytotoxic Activity on Cultured Tumor Cells from a Real Case of Breast Cancer Jessica R. Gutierrez-Cano Multidisciplinaria (Ciencias Naturales y Exactas) Maleimide Doxorubicin cer treatment Breast cancer synergistic can Synthesis and Biological Evaluation of New 3,4-diarylmaleimides as Enhancers (modulators) of Doxorubicin Cytotoxic Activity on Cultured Tumor Cells from a Real Case of Breast Cancer Jessica R. Gutierrez-Cano Pradip D. Nahide Velayudham Ramadoss Yuvraj Satkar Rafael Ortiz-Alvarado Clara Alba-Betancourt Claudia L. Mendoza-Macías César R. Solorio-Alvarado Multidisciplinaria (Ciencias Naturales y Exactas) Maleimide Doxorubicin cer treatment Breast cancer synergistic can A series of new 3,4-diarylmaleimides were synthesized in an optimized and efficient lineal sequence of three steps, starting from commercial maleimide. The biological evaluation of these compounds as enhancers (activity modulators) in the co-administration with doxo - rubicin treatment in breast cancer cells directly obtained from a pa - tient, were essayed. The cancerous tissue BT026-512N was provided by the National Institute of Cancerology (INCAN) of México. This tissue was obtained by biopsy from a patient diagnosed with stage IIB ductal breast cancer. The results obtained in the assays, show de - creased cell viability on the cultured cells for all of the maleimides synthesized in combinatorial administration with doxorubicin. The highest mortality effect was determined for maleimides 9 and 29 in - creased in close to three times the effect compared with treatment us - ing only doxorubicin. Based on previous functionalized maleimides core reports and Molinspiration chemoinformatic analysis, these re - sults could possibly point out to the Pg-p glycoprotein as bio-molecu - lar action target of maleimides by kinase phosphorylation-inhibition, although more experimental data is necessary. 2017 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47551118006 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.1 Vol.61 |
| title | Synthesis and Biological Evaluation of New 3,4-diarylmaleimides as Enhancers (modulators) of Doxorubicin Cytotoxic Activity on Cultured Tumor Cells from a Real Case of Breast Cancer |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Maleimide Doxorubicin cer treatment Breast cancer synergistic can |
| url | https://www.redalyc.org/articulo.oa?id=47551118006 |