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| Format: | Artículo científico |
| Language: | en |
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Sociedad Química de México
2017
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| Online Access: | https://www.redalyc.org/articulo.oa?id=47552182011 |
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| _version_ | 1866558071298326528 |
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| author | Erik Ekengard |
| author_facet | Erik Ekengard |
| contents | A pyrazine amide – 4-aminoquinoline hybrid and its rhodium and iridium pentamethylcyclopentadienyl complexes; evaluation of anti-mycobacterial and anti-plasmodial activities Erik Ekengard Ida Bergare Josefine Hansson Isa Doverbratt Magda Monari Bhavna Gordhan Bavesh Kana Carmen de Kock Peter J. Smith Ebbe Nordlander Multidisciplinaria (Ciencias Naturales y Exactas) half Malaria sandwich chloroquine tuberculosis The synthesis and characterization of N-(2-((7-chloroquinolin- 4-yl)amino)ethyl)pyrazine-2-carboxamide (L), an aminoquinoline – pyrazinamide hybrid, and the complexes (N-(2-((7-chloroquinolin- 4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl) chlorido-rhodium or iridium hexafluorophosphate ([M(L)(Cp*)Cl] PF6; M = Rh, Ir) and the corresponding chlorido salts ([M(L)(Cp*) Cl]Cl; M = Rh, Ir) are described. The ligand and the hexafluorophosphate salts of the metal complexes have been evaluated for anti-plasmodial and anti-mycobacterial activity. The rhodium and the iridium complexes were significantly more active against M. tuberculosis than the free ligand. The crystallographically determined molecular structures of complexes (N-(2-((7-chloroquinolin-4-yl)amino)ethyl) pyrazine-2-carboxamide)(cyclopentadienyl)chlororhodium hexafluoro- phosphate and (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine- 2-carboxamide)(cyclopentadienyl)chloro-iridium chloride are presented. 2017 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47552182011 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.2 Vol.61 |
| format | Artículo científico |
| id | redalyc_47552182011 |
| language | en |
| publishDate | 2017 |
| publisher | Sociedad Química de México |
| spellingShingle | A pyrazine amide – 4-aminoquinoline hybrid and its rhodium and iridium pentamethylcyclopentadienyl complexes; evaluation of anti-mycobacterial and anti-plasmodial activities Erik Ekengard Multidisciplinaria (Ciencias Naturales y Exactas) half Malaria sandwich chloroquine tuberculosis A pyrazine amide – 4-aminoquinoline hybrid and its rhodium and iridium pentamethylcyclopentadienyl complexes; evaluation of anti-mycobacterial and anti-plasmodial activities Erik Ekengard Ida Bergare Josefine Hansson Isa Doverbratt Magda Monari Bhavna Gordhan Bavesh Kana Carmen de Kock Peter J. Smith Ebbe Nordlander Multidisciplinaria (Ciencias Naturales y Exactas) half Malaria sandwich chloroquine tuberculosis The synthesis and characterization of N-(2-((7-chloroquinolin- 4-yl)amino)ethyl)pyrazine-2-carboxamide (L), an aminoquinoline – pyrazinamide hybrid, and the complexes (N-(2-((7-chloroquinolin- 4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl) chlorido-rhodium or iridium hexafluorophosphate ([M(L)(Cp*)Cl] PF6; M = Rh, Ir) and the corresponding chlorido salts ([M(L)(Cp*) Cl]Cl; M = Rh, Ir) are described. The ligand and the hexafluorophosphate salts of the metal complexes have been evaluated for anti-plasmodial and anti-mycobacterial activity. The rhodium and the iridium complexes were significantly more active against M. tuberculosis than the free ligand. The crystallographically determined molecular structures of complexes (N-(2-((7-chloroquinolin-4-yl)amino)ethyl) pyrazine-2-carboxamide)(cyclopentadienyl)chlororhodium hexafluoro- phosphate and (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine- 2-carboxamide)(cyclopentadienyl)chloro-iridium chloride are presented. 2017 artículo científico 1870-249X https://www.redalyc.org/articulo.oa?id=47552182011 en http://www.redalyc.org/revista.oa?id=475 Journal of the Mexican Chemical Society application/pdf Sociedad Química de México Journal of the Mexican Chemical Society (México) Num.2 Vol.61 |
| title | A pyrazine amide – 4-aminoquinoline hybrid and its rhodium and iridium pentamethylcyclopentadienyl complexes; evaluation of anti-mycobacterial and anti-plasmodial activities |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) half Malaria sandwich chloroquine tuberculosis |
| url | https://www.redalyc.org/articulo.oa?id=47552182011 |