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| Format: | Artículo científico |
| Language: | en |
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Universidad de Valparaíso
2013
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| Online Access: | https://www.redalyc.org/articulo.oa?id=47926382002 |
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Table of Contents:
- Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis Ignacio Sottorff Ambbar Aballay Víctor Hernández Luis Roa Lilian X. Muñoz Mario Silva José Becerra Allisson Astuya Ciencias de la Tierra saponins Holothuria holothurinoside D In the last decade, the interest for searching molecules with biomedical potential as well as innocuous for the environment has been increased. Under this perspective, the search for bioactive principles of marine origin has allowed to value the biological diversity present in aquatic systems. In phylum Echinodermata, the family Holothuridae is distinguished by its capacity of synthesizing molecules such as saponins and other secondary metabolites of high pharmacological interest because of their interesting haemolytic, antitumor, anti-inflammatory, antimicrobial, cytostatic and antineoplastic capacity. The aim of the present study was focused on the characterization of a purified extract obtained from Athyonidium chilensis (Holothuria) by chromatographic and mass spectrometric techniques and the later assessment of its bioactive potential on in vitro models. As a result of these analyses 2 saponins were identified. The first with a molecular weight of 1522 Da and highly conjugated with monosaccharides. The second with a molecular weight of 764 Da was identified as holothurinoside D. The biological activity of the purified extract showed antibacterial, antifungal and cytotoxic activity on a neuroblastoma cell line. Outcomes of this study correspond to the first characterization of molecules with biological activity from Athyonidium chilensis. 2013 artículo científico 0717-3326 https://www.redalyc.org/articulo.oa?id=47926382002 en http://www.redalyc.org/revista.oa?id=479 Revista de Biología Marina y Oceanografía application/pdf Universidad de Valparaíso Revista de Biología Marina y Oceanografía (Chile) Num.1 Vol.48