Modulación de la respuesta inmune por los lipopolisacáridos bacterianos
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| Format: | Artículo científico |
| Sprache: | es |
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Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2016
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| author | Gustavo Aldapa-Vega |
| author_facet | Gustavo Aldapa-Vega |
| contents | Modulación de la respuesta inmune por los lipopolisacáridos bacterianos Gustavo Aldapa-Vega Rodolfo Pastelín-Palacios Armando Isibasi Mario A. Moreno-Eutimio Constantino López-Macías Medicina Toll like receptor 4 Immunomodulation Lipopolysaccharide Lipopolysaccharide (LPS) is a molecule that is profusely found on the outer membrane of Gram- negative bacteria and is also a potent stimulator of the immune response. As the main molecule on the bacterial surface, is also the most biologically active. The immune response of the host is activated by the recognition of LPS through Toll-like receptor 4 (TLR4) and this receptor-ligand interaction is closely linked to LPS structure. Microorganisms have evolved systems to control the expression and structure of LPS, producing structural variants that are used for modulating the host immune responses during infection. Examples of this include Helicobacter pylori, Francisella tularensis, Chlamydia trachomatis and Salmonella spp . High concentrations of LPS can cause fever, increased heart rate and lead to septic shock and death. However, at relatively low concentrations some LPS are highly active immunomodulators, which can induce non-specific resistance to invading microorganisms. The elucidation of the molecular and cellular mechanisms involved in the recognition of LPS and its structural variants has been fundamental to understand inflammation and is currently a pivotal field of research to understand the innate immune response, inflammation, the complex host-pathogen relationship and has important implications for the rational development of new immunomodulators and adjuvants. 2016 artículo científico 0002-5151 https://www.redalyc.org/articulo.oa?id=486755025002 es http://www.redalyc.org/revista.oa?id=4867 Revista Alergia México application/pdf Colegio Mexicano de Inmunología Clínica y Alergia, A.C. Revista Alergia México (México) Num.3 Vol.63 |
| format | Artículo científico |
| id | redalyc_486755025002 |
| institution | Redalyc |
| language | es |
| publishDate | 2016 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| spellingShingle | Modulación de la respuesta inmune por los lipopolisacáridos bacterianos Gustavo Aldapa-Vega Medicina Toll like receptor 4 Immunomodulation Lipopolysaccharide Modulación de la respuesta inmune por los lipopolisacáridos bacterianos Gustavo Aldapa-Vega Rodolfo Pastelín-Palacios Armando Isibasi Mario A. Moreno-Eutimio Constantino López-Macías Medicina Toll like receptor 4 Immunomodulation Lipopolysaccharide Lipopolysaccharide (LPS) is a molecule that is profusely found on the outer membrane of Gram- negative bacteria and is also a potent stimulator of the immune response. As the main molecule on the bacterial surface, is also the most biologically active. The immune response of the host is activated by the recognition of LPS through Toll-like receptor 4 (TLR4) and this receptor-ligand interaction is closely linked to LPS structure. Microorganisms have evolved systems to control the expression and structure of LPS, producing structural variants that are used for modulating the host immune responses during infection. Examples of this include Helicobacter pylori, Francisella tularensis, Chlamydia trachomatis and Salmonella spp . High concentrations of LPS can cause fever, increased heart rate and lead to septic shock and death. However, at relatively low concentrations some LPS are highly active immunomodulators, which can induce non-specific resistance to invading microorganisms. The elucidation of the molecular and cellular mechanisms involved in the recognition of LPS and its structural variants has been fundamental to understand inflammation and is currently a pivotal field of research to understand the innate immune response, inflammation, the complex host-pathogen relationship and has important implications for the rational development of new immunomodulators and adjuvants. 2016 artículo científico 0002-5151 https://www.redalyc.org/articulo.oa?id=486755025002 es http://www.redalyc.org/revista.oa?id=4867 Revista Alergia México application/pdf Colegio Mexicano de Inmunología Clínica y Alergia, A.C. Revista Alergia México (México) Num.3 Vol.63 |
| title | Modulación de la respuesta inmune por los lipopolisacáridos bacterianos |
| topic | Medicina Toll like receptor 4 Immunomodulation Lipopolysaccharide |
| url | https://www.redalyc.org/articulo.oa?id=486755025002 |