Síndrome hiper-IgE. Lecciones de la función y defectos de STAT-3 o DOCK-8
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| Formato: | Artículo científico |
| Lenguaje: | es |
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Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2016
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| _version_ | 1876444726016606208 |
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| author | Julio César Alcántara-Montiel |
| author_facet | Julio César Alcántara-Montiel |
| contents | Síndrome hiper-IgE. Lecciones de la función y defectos de STAT-3 o DOCK-8 Julio César Alcántara-Montiel Brittany Itzel Vega-Torres Medicina DOCK STAT Hyper IgE syndrome Primary immunodeficiency In the classification of primary immunodeficiencies, hyper-IgE syndrome, identified with OMIM code # 147060 in the Online Mendelian Inheritance in Man catalog, belongs to the group of syndromes associated with combined immunodeficiencies. It is characterized by elevated levels of IgE, eosinophilia, recurrent skin abscesses, pneumonia, lung parenchyma lesions, recurrent infections, rashes in newborns, eczema, sinusitis, otitis, and mucocutaneous candidiasis. Hyper-IgE syndrome can be transmitted by autosomal dominant or autosomal recessive modes of inheritance. Hyper-IgE syndrome in its dominant form includes non-immunological manifestations like characteristic facies, pathological dentition, scoliosis, bone disorders, and joint hyperextensibility. The reported cause of the dominant form is the loss of function of the signal transducer and activator of transcription 3 (STAT-3, with MIM # 102582). Mutations in dedicator of cytokines 8 (DOCK-8) is the most common cause of the autosomal recessive form of hyper-IgE syndrome. 2016 artículo científico 0002-5151 https://www.redalyc.org/articulo.oa?id=486755026008 es http://www.redalyc.org/revista.oa?id=4867 Revista Alergia México application/pdf Colegio Mexicano de Inmunología Clínica y Alergia, A.C. Revista Alergia México (México) Num.4 Vol.63 |
| format | Artículo científico |
| id | redalyc_486755026008 |
| institution | Redalyc |
| language | es |
| publishDate | 2016 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| spellingShingle | Síndrome hiper-IgE. Lecciones de la función y defectos de STAT-3 o DOCK-8 Julio César Alcántara-Montiel Medicina DOCK STAT Hyper IgE syndrome Primary immunodeficiency Síndrome hiper-IgE. Lecciones de la función y defectos de STAT-3 o DOCK-8 Julio César Alcántara-Montiel Brittany Itzel Vega-Torres Medicina DOCK STAT Hyper IgE syndrome Primary immunodeficiency In the classification of primary immunodeficiencies, hyper-IgE syndrome, identified with OMIM code # 147060 in the Online Mendelian Inheritance in Man catalog, belongs to the group of syndromes associated with combined immunodeficiencies. It is characterized by elevated levels of IgE, eosinophilia, recurrent skin abscesses, pneumonia, lung parenchyma lesions, recurrent infections, rashes in newborns, eczema, sinusitis, otitis, and mucocutaneous candidiasis. Hyper-IgE syndrome can be transmitted by autosomal dominant or autosomal recessive modes of inheritance. Hyper-IgE syndrome in its dominant form includes non-immunological manifestations like characteristic facies, pathological dentition, scoliosis, bone disorders, and joint hyperextensibility. The reported cause of the dominant form is the loss of function of the signal transducer and activator of transcription 3 (STAT-3, with MIM # 102582). Mutations in dedicator of cytokines 8 (DOCK-8) is the most common cause of the autosomal recessive form of hyper-IgE syndrome. 2016 artículo científico 0002-5151 https://www.redalyc.org/articulo.oa?id=486755026008 es http://www.redalyc.org/revista.oa?id=4867 Revista Alergia México application/pdf Colegio Mexicano de Inmunología Clínica y Alergia, A.C. Revista Alergia México (México) Num.4 Vol.63 |
| title | Síndrome hiper-IgE. Lecciones de la función y defectos de STAT-3 o DOCK-8 |
| topic | Medicina DOCK STAT Hyper IgE syndrome Primary immunodeficiency |
| url | https://www.redalyc.org/articulo.oa?id=486755026008 |