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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Universidad Nacional de Colombia
2016
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=49647009006 https://www.redalyc.org/journal/496/49647009006/ https://www.redalyc.org/journal/496/49647009006/html/ https://www.redalyc.org/journal/496/49647009006/49647009006.epub https://www.redalyc.org/journal/496/49647009006/movil |
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Sommario:
- Modeling and behavior of the simulation of electric propagation during deep brain stimulation Pablo A. Alvarado Cristian A. Torres-Valencia Álvaro A. Orozco-Gutiérrez Mauricio A. Álvarez Genaro Daza-Santacoloma Hans Carmona-Villada Ingeniería DBS FEM Laplace equation Parkinson disease electric brain propagation Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease. In the literature, there are a wide variety o f mathematical and computational models to describe electric propagation during DBS; however unfortunately, there is no clarity about the reasons that justify the us e of a specific model. In this work, we present a detailed mathematical formulation of the DBS electric propagation that suppor ts t he use of a model based on the Laplace Equation. Moreover, we performed DBS simulations for several geometrical models of the brain in order to determine whether geometry size, shape and ground location influence electric stimulation prediction by using th e Finite Element Method (FEM). Theoretical and experimental analysis show, firstly, that under the correct assumptions, the Laplace equation is a suitable alternative to de scribe the electric propagation, and secondly, that geometrical structure, size and grounding of the head volume affect the magnitude of the electric potential, particularly for monopolar stimulation. Results show that, for monopolar stimulation, basic and more realistic models can dif fer more than 2900%. 2016 artículo científico 0012-7353 https://www.redalyc.org/articulo.oa?id=49647009006 https://www.redalyc.org/journal/496/49647009006/ https://www.redalyc.org/journal/496/49647009006/html/ https://www.redalyc.org/journal/496/49647009006/49647009006.epub https://www.redalyc.org/journal/496/49647009006/movil en http://www.redalyc.org/revista.oa?id=496 Dyna application/pdf Universidad Nacional de Colombia Dyna (Colombia) Num.198 Vol.83